研究目的
Investigating the biocompatibility of micro/nanostructures on nitinol surface fabricated via nanosecond laser circularly scanning for enhancing osseointegration and bioactivity of nitinol implants.
研究成果
Nanosecond laser circularly scanning can produce various micro/nanostructures on nitinol, enhancing its biocompatibility and osseointegration potential. The donuts-like shape surface showed the best cell proliferation effect.
研究不足
The study focuses on in vitro biocompatibility evaluation; in vivo studies are needed to fully assess the biocompatibility and osseointegration potential of the treated surfaces.
1：Experimental Design and Method Selection:
Three novel scanning patterns (donuts-like shape, hotdogs-like shape, banana-like shape) were designed for fabricating micro/nanostructures on nitinol surface using a nanosecond laser.
2：Sample Selection and Data Sources:
Nitinol sheets (Ti-
3：72wt.%Ni) with negligible roughness were used. List of Experimental Equipment and Materials:
A semiconductor-pumped solid-state DPSS nanosecond laser, SEM (JSM-7001F, JEOL, Japan), EDS (QX200, Bruker, Germany), XPS (Thermo ESCALAB 250XI, Thermo?scher, America), and laser scanning confocal microscopy (LSCM, C2Plus, Nikon, Japan).
4：Experimental Procedures and Operational Workflow:
Laser scanning was performed in open atmosphere with specific parameters. Surface morphology and elements were analyzed post-treatment. MC3T3-E1 osteoblast cells were cultured on the surfaces for biocompatibility evaluation.
5：Data Analysis Methods:
SEM for morphology, EDS and XPS for chemical composition, LSCM for cell viability, and MTT assay for cell proliferation.
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