研究目的
To compare the panretinal photocoagulation (PRP)–induced pain response between novel navigated laser (Navilas) and conventional single-spot laser.
研究成果
Navilas is capable of producing more precise laser spots with lower energy levels and shorter pulse durations causing significant decrease in pain perception during laser photocoagulation and can increase the patient’s compliance with the laser treatment.
研究不足
Small number of patients treated with same pulse duration and different contact lenses used for two systems should be taken into consideration. Besides, we did not report comparative clinical efficiency of either laser system.
1：Experimental Design and Method Selection:
The study was prospectively designed to compare pain response during PRP between Navilas and conventional laser systems. Eyes were randomly assigned to one system, with contralateral eyes treated with the other system after a 30-minute rest. Pain was evaluated using verbal and visual analog scales.
2：Sample Selection and Data Sources:
70 patients (140 eyes) with bilateral high-risk proliferative diabetic retinopathy were enrolled. Exclusion criteria included history of vitrectomy, ocular trauma, and media opacities.
3：List of Experimental Equipment and Materials:
Navilas laser system (OD-OS GmbH, Teltow, Germany) and conventional laser (ELLEX Integre, Adailade, Australia) were used. Mainster PRP lens and a proprietary lens specific to Navilas were used for visualization.
4：Experimental Procedures and Operational Workflow:
PRP was performed with Navilas or conventional laser in one eye randomly and with the other system in the fellow eye. Laser parameters were set to create gray-white burns, with pain evaluated post-procedure.
5：Data Analysis Methods:
Statistical analysis was performed using SPSS 18.0, with data comparison made using Mann-Whitney U test and Wilcoxon test.
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