研究目的
To evaluate the effectiveness of a near-infrared-light-sensitive photovoltaic subretinal prosthesis in restoring visual perception in non-human primates with induced blindness, as a step towards clinical application in humans with dry atrophic age-related macular degeneration.
研究成果
The photovoltaic subretinal prosthesis effectively restored visual perception in non-human primates, as evidenced by behavioral responses to near-infrared light stimulation. The implant's high spatial resolution and stability over two years post-implantation support its potential for clinical evaluation in humans with dry atrophic age-related macular degeneration.
研究不足
The study's limitations include the small sample size of non-human primates, the potential differences in retinal response between primates and humans, and the need for long-term evaluation of the implant's stability and effectiveness.
1：Experimental Design and Method Selection:
The study involved the implantation of a photovoltaic subretinal prosthesis in non-human primates to evaluate its effectiveness in restoring visual perception. The prosthesis was activated using near-infrared light, and the animals' behavioral responses were monitored.
2：Sample Selection and Data Sources:
Three awake non-human primates (Macaca fascicularis) were used in the study. The retinal tissues were harvested and cultured for in vitro experiments, and behavioral responses were recorded in vivo.
3：List of Experimental Equipment and Materials:
The study utilized a photovoltaic subretinal implant, near-infrared laser (880 nm, 2.5 W), digital micromirror device (DMD), multi-electrode array (MEA), and optical coherence tomography (OCT) for imaging.
4：5 W), digital micromirror device (DMD), multi-electrode array (MEA), and optical coherence tomography (OCT) for imaging.
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: The prosthesis was implanted subretinally in the primates. Behavioral responses to near-infrared light stimulation were assessed through eye tracking and saccade detection tasks. In vitro experiments involved culturing retinal tissues and recording retinal ganglion cell (RGC) responses to implant stimulation.
5：Data Analysis Methods:
The data were analyzed to determine the threshold for RGC activation, the spatial resolution of the implant, and the behavioral responses of the primates to stimulation.
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