研究目的
To design a benzothiadiazole-based covalent organic framework (COF) with slipped structure to promote two-photon absorption (TPA) performance and achieve efficient two-photon excited fluorescence for near-infrared excited fluorescence imaging.
研究成果
The study demonstrates that TPA-COF can work as a promising candidate with efficient TPA performance by utilizing the unique crystalline feature of COF. The slipped structure, long-range crystal domain, and π-conjugation domain of the corresponding monomer greatly improve the delocalization of π-electrons, leading to high dipole value and TPA activity. This work offers a pathway to overcome aggregation-caused quenching and acquire near-infrared two-photon excited COFs for future biomedical applications.
研究不足
The study is limited by the need for further optimization of the COF structure to enhance TPA performance and the exploration of its applications in more complex biological systems.
1：Experimental Design and Method Selection:
The synthesis of TPA-COF was achieved by solvothermal reaction of benzothiadiazole-based aldehyde molecular chromophores with aniline building blocks.
2：Sample Selection and Data Sources:
The structure of TPA-COF was characterized by Fourier transform infrared (FT-IR) spectrum, CP/MAS 13C solid-state nuclear magnetic resonance (NMR) spectrum, and N2 adsorption-desorption at 77 K.
3：List of Experimental Equipment and Materials:
Instruments used include SEM, TEM, STEM, ED, HR-TEM, and PXRD.
4：Experimental Procedures and Operational Workflow:
The crystallinity of TPA-COF was reflected in the sharp peaks in the PXRD patterns. The two-photon action across-section was determined by using the femtosecond fluorescence measurement technique.
5：Data Analysis Methods:
The PXRD pattern was refined against simulated COF structure by Pawley refinement. The two-photon fluorescence imaging was measured by two-photon electrophysiological microscope.
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