研究目的
To quantitatively and systematically study the photothermal therapy using NIR and graphene, and in doing so to suggest ways to optimize cancer photothermal therapy.
研究成果
Higher concentration of graphene nanosheets would result in a higher temperature increase rate for both the normal tissue and the cancer cell. Graphene sheets with shorter length, and bigger width/thickness could induce a higher temperature increase rate of the cancer cell due to the presence of graphene sheets acting as effective local heating agents. Reducing the interfacial thermal resistance between the cancer cell and graphene is another approach to induce higher temperature increase rate of the cancer cell, which can be possibly achieved by proper functionalization of the graphene.
研究不足
Monte Carlo methods are limited by computational capabilities, when one would need to simulate a much larger physical system.
1：Experimental Design and Method Selection:
A mesoscale model of photothermal therapy using NIR and functionalized graphene is developed based on a Monte Carlo (MC) method. A three-dimensional model with a cancer cell and randomly distributed graphene sheets is built to model the photothermal therapy of cancer using NIR and graphene.
2：Sample Selection and Data Sources:
A cube with side of 2 μm represented healthy tissue and a sphere with diameter of 1 μm was used to model a cancer cell. Graphene nanosheets were built as cuboids with thickness of 2 nm, length of 100 nm and width of 10 nm.
3：List of Experimental Equipment and Materials:
The system was assumed to be under illumination of an 808 nm laser from the top surface.
4：Experimental Procedures and Operational Workflow:
Heat transport was modeled by using randomly moving heat walkers, each one carrying the same amount of thermal energy. The computational box was divided into 150 grid points on each side (total of 150×150×150 computational mesh cells).
5：Data Analysis Methods:
The temperature distribution was calculated by counting the number of walkers in each one of the computational mess cells.
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