研究目的
Investigating the construction of self-assembled nanostructures using protein and DNA through Watson-Crick base-pairing of DNAs for biomedical applications.
研究成果
The study successfully constructs linear arrays of supramolecular building blocks made of traptavidins and DNAs through step-growth polymerization and magnetic separation. These arrays serve as templates for precisely locating gold nanoparticles, forming plasmonic nanostructures with predetermined inter-particle spacings, promising for biosensing and bioimaging applications.
研究不足
The study involves sophisticated interactions and may cause a high degree of disorder in the assembly of protein nanostructures. The method's precision in controlling the number of biotinylated DNAs attached to AuNPs is not guaranteed.
