摘要： The coupling of Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) with laser combines the attributes of laser mass spectrometry with the analytical capabilities of a mass spectrometer having high resolution, high mass measurement accuracy, long ion-observation times, and exceptional ion isolation capabilities required for ion-molecule reaction or ion fragmentation studies [1–3]. The laser may be used for different purposes in mass spectrometry. The most standard one is to generate ions from the surface of the laser-irradiated sample. Two regimes have to be considered in respect with the laser fluence (energy deposit per surface unit in J/cm2) or the laser power density also named irradiance (power density deposit per surface unit in W/cm2). At low laser fluence, laser desorption/ionization (LDI) may take place. When the laser fluence increases, the regime of laser–matter interaction is modified and laser ablation (LA) occurs. In both cases, the ionization phenomenon and the transfer of the atoms or molecules to the gas phase are the direct result of the laser matter interaction. LDI and LA are well suited to the analysis of a wide range of organic, inorganic and also biological compounds. For complex matrices, it is important to note that information may be obtained on both organic and inorganic species. This is of first importance for the study of environmental or composite samples for example, in which organics, inorganics and/or polymers are intimately associated.