研究目的
To develop methods for controlled fabrication of nuclear agents carrying nanoparticles with low polydispersity and high colloidal stability in aqueous dispersions for nuclear therapy.
研究成果
The study successfully demonstrated the fabrication of isotope-enriched samarium oxide nanoparticles with controlled size and high colloidal stability using femtosecond laser ablation and fragmentation. These NPs are promising for nuclear therapy, catalysis, and biomedical applications.
研究不足
The initial laser ablation step produces NPs with wide size and shape dispersion, requiring an additional fragmentation step for homogenization. The technique's scalability and the potential for residual contamination from the ablation target are concerns.
1：Experimental Design and Method Selection:
Femtosecond laser ablation and fragmentation in deionized water were used to fabricate stable aqueous dispersion of 152Sm-enriched samarium oxide nanoparticles.
2：Sample Selection and Data Sources:
Samarium oxide micropowder enriched with 152Sm isotope was used as the target material.
3：List of Experimental Equipment and Materials:
Yb:KGW laser (1030 nm wavelength, 270 fs pulse duration), BK-7 glass vessel, ultrapure water, carbon-coated copper grid for TEM imaging.
4：Experimental Procedures and Operational Workflow:
The target was ablated in water with varying laser pulse energies, followed by a fragmentation step to homogenize NP sizes.
5：Data Analysis Methods:
Morphology, structure, size, and composition of NPs were characterized by STEM and EDS; ζ–potential measurements were performed to assess colloidal stability.
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