研究目的
To assess factors associated with receipt of subsequent medical, laser, or surgical interventions after laser peripheral iridotomy (LPI) in patients with narrow angles (NAs).
研究成果
African Americans were more likely than whites to carry a diagnosis of PAC or PACG at the time of LPI and were significantly more likely to be prescribed additional glaucoma medications and require glaucoma surgery after LPI. Improved screening methods that target African Americans with NAs are needed for earlier preventive interventions.
研究不足
Retrospective nature limited the types of available data, and follow-up time was variable. Biometry, anterior segment OCT, and ultrasound biomicroscopy imaging were not consistently obtained. Gonioscopy was only performed after LPI if needed, so the angle's openness after LPI could not be confirmed in all patients.
1:Experimental Design and Method Selection:
Retrospective review of patients treated with LPI for narrow angles. Logistic regression with generalized estimating equations and Cox proportional-hazards regression analysis were used.
2:Sample Selection and Data Sources:
1271 eyes in 692 subjects with narrow angles treated with LPI. Data collected from Duke University Medical Center.
3:List of Experimental Equipment and Materials:
Goldmann applanation tonometry (model AT900; Haag-Streit AG), Ocular Zeiss 4-mirror hand-held goniolens (Ocular Instruments, Inc), Argon diode laser, neodymium-doped yttrium aluminum garnet laser.
4:Experimental Procedures and Operational Workflow:
Demographic and clinical factors were assessed. LPI was performed, and follow-up data on subsequent interventions were collected.
5:Data Analysis Methods:
Statistical analysis was completed in STATA 15.1. Logistic regression and Cox proportional-hazards regression analysis were used.
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