研究目的
Investigating the influence of uncertainty in the conductivity of bone tissue on the electric field strength and the beneficial stimulation volume for an optimized electrode geometry and arrangement in an electrostimulative total hip revision system.
研究成果
The results suggest that the overall beneficial stimulation areas are only slightly sensitive to the uncertainty in conductivity of bone tissue. However, in the proximity of tissue boundaries, larger uncertainties, especially in the transition between beneficial and understimulation areas, can be expected. The optimized electrode arrangements and locations are quite insensitive to uncertainty in the conductivity of bone tissue as modeled in this study.
研究不足
The study is limited by the computational expense and time required for the uncertainty quantification in the model solutions. Additionally, the optimal thresholds for the electric field strength to provide beneficial stimulation are still subject to ongoing research.
1:Experimental Design and Method Selection:
Computational models of an electrostimulative total hip revision system were developed to enhance bone regeneration. The influence of uncertainty in the conductivity of bone tissue on the electric field strength and the beneficial stimulation volume was investigated using the generalized polynomial chaos technique.
2:Sample Selection and Data Sources:
The study used realistic 3-D models of the pelvic and femoral bone attached to models of an acetabular component and femoral component of a prototype system.
3:List of Experimental Equipment and Materials:
The study utilized computational modeling software (CST EM Studio) for the computation of the electric field distribution.
4:Experimental Procedures and Operational Workflow:
The electric potential in the bone tissue and at the surface of the implant was computed by solving Laplace’s equation within the computational domain. The optimization of the electrode arrangements and geometry was carried out to provide optimal beneficial stimulation in the proximity of the surface of the implants.
5:Data Analysis Methods:
The generalized polynomial chaos technique was used to quantify the uncertainty in the stimulation volumes with respect to the uncertain conductivity of cancellous bone, bone marrow, and bone substitute.
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