研究目的
Investigating the influence of uncertainty in the conductivity of bone tissue on the electric field strength and the beneficial stimulation volume for an optimized electrode geometry and arrangement in an electrostimulative total hip revision system.
研究成果
The results suggest that the overall beneficial stimulation areas are only slightly sensitive to the uncertainty in conductivity of bone tissue. However, in the proximity of tissue boundaries, larger uncertainties, especially in the transition between beneficial and understimulation areas, can be expected. The optimized electrode arrangements and locations are quite insensitive to uncertainty in the conductivity of bone tissue as modeled in this study.
研究不足
The study focuses on the computational modeling and simulation of an electrostimulative hip revision system, and the results are based on theoretical models. The actual clinical application may have additional constraints and variables not considered in the study.
1:Experimental Design and Method Selection:
Computational models of an electrostimulative total hip revision system were developed to enhance bone regeneration. The influence of uncertainty in the conductivity of bone tissue on the electric field strength and the beneficial stimulation volume was investigated using the generalized polynomial chaos technique.
2:Sample Selection and Data Sources:
The study used realistic 3-D models of the pelvic and femoral bone attached to the acetabular and femoral components of a prototype system.
3:List of Experimental Equipment and Materials:
The study utilized computational models and software (CST EM Studio) for simulating the electric field distribution.
4:Experimental Procedures and Operational Workflow:
The electric potential in the bone tissue and at the surface of the implant was computed by solving Laplace's equation within the computational domain. The optimization of the electrode arrangement and geometry was carried out using multiobjective optimization algorithms.
5:Data Analysis Methods:
The generalized polynomial chaos technique was used to quantify the uncertainty in the stimulation volumes with respect to the uncertain conductivity of cancellous bone, bone marrow, and bone substitute.
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