研究目的
Investigating the synthesis and characterization of a novel radiolabeled fluorescent nanocomposite for potential use in PET imaging and cancer therapy.
研究成果
The study successfully synthesized a novel radiolabeled fluorescent nanocomposite with potential for PET imaging and cancer therapy. The nanocomposite showed rapid tumor uptake and fast clearance from the body, indicating its promise as a theranostic agent.
研究不足
The study focuses on the synthesis and preliminary in vivo evaluation of the nanocomposite. Further studies are needed to assess long-term stability, toxicity, and efficacy in clinical settings.
1：Experimental Design and Method Selection:
The study involved the synthesis of SH-Propyl@MCM-41, grafting of CdTe QDs onto it, and radiolabeling with 68Ga. Characterization was performed using various techniques including XRD, TGA, RTLC, FE-SEM, TEM, and N2 adsorption-desorption measurements.
2：Sample Selection and Data Sources:
MCM-41 was synthesized and functionalized with MPTMS. CdTe QDs were synthesized and grafted onto the functionalized MCM-
3：List of Experimental Equipment and Materials:
STOE diffractometer, Rheometric Scientific STA-1500, Quantachrome Nova equipment, FEI Tecnai G2F30 microscope, Zeiss EM900, TeScan – Mira III.
4：Experimental Procedures and Operational Workflow:
The synthesis involved refluxing MCM-41 with MPTMS, grafting CdTe QDs, and radiolabeling with 68Ga. Characterization was performed as per standard protocols.
5：Data Analysis Methods:
Data from XRD, TGA, RTLC, FE-SEM, TEM, and N2 adsorption-desorption were analyzed to confirm the structure and properties of the nanocomposite.
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