研究目的
To synthesize a hybrid fluorescent nanosensor for the detection of D-glucose, utilizing phenylboronic acid-functionalized POSS and diol-modified ANSA, and to evaluate its glucose sensing ability under various conditions.
研究成果
The POSS-APBA-dye probe demonstrated effective glucose sensing capabilities, with a good linear relationship at low glucose concentrations and stability in a pH 5 environment. The probe's performance was largely unaffected by interfering substances, and it showed long-term fluorescence stability. This suggests potential applications in glucose monitoring, particularly at low concentrations.
研究不足
The study focused on the synthesis and initial evaluation of the POSS-APBA-dye probe. Further research is needed to optimize the probe's performance and to explore its application in real-world scenarios, such as in vivo glucose monitoring.
1：Experimental Design and Method Selection:
The study involved the synthesis of a hybrid fluorescent nanosensor using phenylboronic acid-functionalized POSS and diol-modified ANSA. The probe's structure was characterized by FT-IR and 1H-NMR analyses. The photoluminescence intensity was measured under various conditions to confirm its glucose sensing ability.
2：Sample Selection and Data Sources:
The samples included POSS-APBA-dye and APBA-dye probes. Data on photoluminescence intensity were collected to evaluate glucose sensing performance.
3：List of Experimental Equipment and Materials:
FT-IR (Spectrum Two, Perkin Elmer), 1H-NMR (Ascend tm 500, Bruker), PL intensity measurement (LS 55, Perkin Elmer). Materials included POSS macromer, APBA, PEG, D-glucose, ANSA, hydrazine monohydrate, and NH3 solution.
4：Experimental Procedures and Operational Workflow:
The synthesis involved the reaction of POSS with APBA and the modification of ANSA with PEG. The photoluminescence intensity was measured at various glucose concentrations and pH levels to evaluate the probe's sensing ability.
5：Data Analysis Methods:
The response rate of the probe was calculated based on fluorescence intensity changes. The association constants of diol–boronic acid complexes were determined to understand the probe's performance.
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