研究目的
To develop Gd doped CeO2 nanoparticles as contrast agents for MRI to detect the tumor vascular microenvironment with high sensitivity, focusing on enhancing the sensitivity to acquire information on microvascular permeability and water diffusion.
研究成果
The research demonstrated that CeO2:Gd nanoparticles with oxygen vacancies can serve as effective contrast agents for MRI, enhancing both DCE-PWI and DWI signals. This approach offers a novel strategy for designing MRI contrast agents and provides a more sensitive method for detecting tumor vascular microenvironment characteristics.
研究不足
The study focuses on the synthesis and initial testing of CeO2:Gd nanoparticles as MRI contrast agents. Further research is needed to optimize their performance and evaluate their safety and efficacy in clinical settings.
1：Experimental Design and Method Selection:
The study involved the synthesis of Gd-doped CeO2 nanoparticles with surface oxygen vacancies, their characterization, and evaluation as MRI contrast agents.
2：Sample Selection and Data Sources:
Ultra-small CeO2:Gd nanoparticles were synthesized and characterized using TEM, XRD, FT-IR, and Raman spectroscopy.
3：List of Experimental Equipment and Materials:
Equipment included a JEOL 200CX TEM, Rigaku D/MAX-2250 V XRD, Nicolet 7000-C FT-IR spectrometer, and a DXR Raman Microscope. Materials included oleylamine, gadolinium nitrate hexahydrate, and DSPE-PEG.
4：Experimental Procedures and Operational Workflow:
The nanoparticles were synthesized, characterized, and then tested for their MRI contrast enhancement properties in vitro and in vivo.
5：Data Analysis Methods:
MRI signal intensities were quantitatively analyzed, and the relaxation rates were calculated to evaluate the contrast enhancement properties.
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