研究目的
Investigating the therapeutic effects of a specific herbal medicine on a particular disease.
研究成果
Porous, drug-containing PCL scaffolds with a designed architecture were successfully manufactured by SLA. The model drug lidocaine was dissolved in the polymer matrix and was released by diffusion. Porosity clearly affected the drug release: porous samples released lidocaine with a burst whereas drug release from solid samples was significantly slower. However, the degree of porosity and surface to mass ratio did not have an effect to the release; instead, the polymer network may be the restricting factor in the diffusion of the drug.
研究不足
The study focused on the effect of scaffold architecture on drug release from PCL scaffolds using lidocaine as a model drug. The findings may not be directly applicable to other drugs or polymer systems. The post-processing step involving solvent extraction may affect drug loading, especially in thin structures.
1：Experimental Design and Method Selection:
The study used stereolithography (SLA) to prepare polycaprolactone scaffold structures containing the model drug lidocaine. The release of lidocaine was studied to analyze the influence of porosity and surface to volume ratio on drug release.
2：Sample Selection and Data Sources:
Polycaprolactone (PCL) macromers were synthesized and mixed with lidocaine to prepare the resin for SLA.
3：List of Experimental Equipment and Materials:
The Envisiontec Perfactory Mini Multilens SLA system was used for printing. Materials included PCL macromer, lidocaine, photoinitiator TPO-L, and Orasol orange dye.
4：Experimental Procedures and Operational Workflow:
The resin was prepared by mixing PCL macromer with lidocaine, photoinitiator, and dye. Structures were printed, post-processed, and then subjected to drug release studies in phosphate buffer solution.
5：Data Analysis Methods:
Drug release was monitored using UV/Vis-spectrophotometry. The data were analyzed to understand the effect of scaffold architecture on drug release.
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