摘要： This review discusses research into the enhancement of the chiroptical spectroscopic technique of Raman optical activity (ROA) through plasmonic resonance effects. The sensitivity of ROA spectroscopy to molecular stereochemistry and conformational dynamics has led to its increasing use in biology and the pharmaceutical sciences. However, the relative weakness of the ROA scattering process, being typically three to five orders of magnitude lower than the parent Raman scattering, has limited its application to conditions of relatively high concentrations and data accumulation times. The potential solution to this limitation in ROA by using the surface plasmon resonances that give rise to surface-enhanced Raman scattering (SERS) in order to boost ROA spectral intensity has been recognized by many researchers. Frustratingly, reliable measurement of this new technique of surface-enhanced Raman optical activity (SEROA) proved challenging to accomplish. A previous review by Abdali and Blanch presented the challenges involved in attempts to measure SEROA, as well as early results. Since then, significant advances have been made in exploring the SEROA phenomenon, and the time is appropriate for an updated account of this work. In order to provide sufficient background for guiding readers into the underlying principles of, and challenges faced in, measuring SEROA, we begin with an introduction to ROA before progressing on to its plasmonically-enhanced form.