研究目的
To explore the multi-directional mechanics of the carotid artery in relation to cardiovascular risk.
研究成果
The elastic modulus index of the carotid artery might serve as a novel surrogate marker of high-risk CVD. The combination of CIMT and elastic modulus index significantly improved the ability to define a high risk of CVD in its early stage, before the occurrence of a cardiovascular event. The supplementary assessment of the mechanical property with CIMT by specialized software lended additional value than that of the CIMT measurement alone.
研究不足
The retrospective design and single-center nature of the study limited our analysis. Assessments of multi-directional mechanics along the longitudinal plane only were recorded. In addition, stiffness measurements were estimated using data from the CCA and only reflect the characteristics of that region of the carotid artery. The high-risk group was relatively small compared to the general population. The high-risk group consisted of relatively more men than the non-high risk group. There were no parameter of arterial stiffness which have significant association with high risk of CVD in women group because only two people of high risk were in women group.
1：Experimental Design and Method Selection:
The study enrolled 401 patients who underwent carotid ultrasound between January 2010 and April
2：A high risk of CVD was defined as more than 20% of 10-year risk based on the Framingham risk score. Using a speckle-tracking technique, the longitudinal and radial movements were analyzed in the B-mode images. Sample Selection and Data Sources:
20 Patients were selected from a consecutive series of 419 patients who visited a single cardiology outpatient clinic, with 18 patients excluded due to specific criteria.
3：List of Experimental Equipment and Materials:
High-resolution B-mode CUS was performed using linear array transducer with 8 MHz center frequency [iE33 echo machine (Philips Medical Systems, Andover, MA, USA) or Vivid7 scanner (GE Medical-Systems, Horten, Norway)].
4：Experimental Procedures and Operational Workflow:
Both common carotid arteries were examined with the head tilted slightly upward in the midline position. At least two consecutive beats were stored and the multi-directional movement of the carotid artery data was analyzed by arterial analysis software.
5：Data Analysis Methods:
Parameters for assessment of multi-directional movement of the carotid artery were calculated using arterial analysis software from the radial measurements. Central BP was measured with pulse wave analysis of the radial artery using tonometry.
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