研究目的
To evaluate the existing research pertaining to PBM applications in the retina, with a focus on the mechanisms of action and clinical outcomes.
研究成果
Given the promising pre-clinical results and the equally promising first few translations to human patients, we should expect a growth in the field of photobiomodulation applied to treat common retinal conditions. Nevertheless, much more work in human subjects as well as in animal models needs to be carried out to better understand the underlying mechanisms of how PBM helps cure and/or prevent retinal damage, establish robust treatment protocols for the various applications, and identify and properly address potential harmful effects on the various tissues that get irradiated during PBM treatments.
研究不足
The large variety of potentially treatable ocular conditions and the wide range of treatment protocols being published in terms of wavelength, treatment session duration, and the total number of treatment sessions make it harder to pull the available data into Meta-analyses for the purpose of developing standardized treatment guidelines. Also, most of the available data stems from small clinical trials, case series, and reports, some of which lack proper controls.