摘要： While the gold nanorods (AuNRs) possess a strong potential application in nanotechnology, plasmonics and sensing, the scale-up synthesis of isolated AuNRs in gram quantity remains a challenge. Nearly all previously reported methods produce aqueous solutions of CTAB-coated AuNRs in milligram quantities with the yield of ~20-30 % in terms of Au (I) to Au (0) conversion. In addition, it is difficult to remove CTAB bilayer from the surface of AuNRs and yet make them soluble and functionalized for further processing and chemical modification. This report describes the synthesis of monodisperse functionalized AuNRs (σ~5%) in gram quantities. Our approach is to increase the concentration of HAuCl4.3H20 in the growth solution to produce larger quantities of starting AuNRs and further reduce the remaining Au (I) ions onto the surface of AuNRs. The slow and controlled addition of reducing agent ascorbic acid (AA) continues to Au (0) (via disproportionation reaction) onto the surface of nanorods maintaining their uniform morphology without creating any unwanted impurities of various shapes. In addition, this approach significantly narrows the size distribution due to the continuous growth of partially grown AuNRs during the initial stage of the synthesis. To isolate one-gram quantity of AuNRs and make them functionalized for further chemical reactions, a ligand exchange approach was utilized where surfactant CTAB was replaced with 4-mercaptophenol. The thiol group from 4-mercaptophenol forms a covalent bond to the surface of AuNRs leaving free functional OH groups available for further chemical coupling reactions. For the ligand exchange process, a concentrated solution of 4-mercaptophenol in tetrahydrofuran (THF) solution was introduced into the AuNRs solution. Pure AuNRs, functionalized with 4-mercaptophenol were isolated by dispersion and rinsing with excess of THF, followed by centrifugation.