研究目的
To explore the intrinsic differences in the optical properties of the nasopharyngeal carcinoma (NPC) and normal tissue by optical coherence tomography (OCT) and to demonstrate that NPC could be diagnosed by visualization.
研究成果
OCT has the potential to be a valuable tool in detecting mucosa abnormalities. It can detect major disruptions to the epithelial layer, lamina propria, and basement membrane layer in mucosa, with sensitivity and specificity of 90% and 100%, respectively.
研究不足
The study is a pilot study with a small sample size. Further research is needed to define precancer diagnosis based on the intensity and the width of epithelium.
1：Experimental Design and Method Selection:
The study used OCT to image normal and NPC tissues to explore their optical properties.
2：Sample Selection and Data Sources:
Five pieces of nasopharyngeal tissues and five pieces of NPC tissue were collected from 10 patients who underwent endoscopic biopsies.
3：List of Experimental Equipment and Materials:
A spectral domain OCT system with a super luminescent diode light source was used.
4：Experimental Procedures and Operational Workflow:
Each biopsy specimen was divided into two parts, one for histopathologic examination and another for OCT measurements.
5：Data Analysis Methods:
The OCT images were analyzed for morphological differences between normal and NPC tissues.
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