研究目的
Investigating the feasibility of using optical coherence tomography (OCT) for imaging the basal ganglia in the rat brain and its potential applications in neurosurgical procedures.
研究成果
OCT technology enabled the visualization of rat brain basal ganglia in vivo and in real-time, similar to histological views. These results suggested that this technique could be used as a precise and sensitive imaging method. The feasibility provided by a simple system apparatus and the possibility to combine with current stereotactic tools may enable the use of this technique in the human brain, thereby improving patient safety and target precision.
研究不足
The small range of tissues that can be imaged by OCT, as a result of low light penetration, could signal limitations for its use when a wider surgical view is necessary.
1：Experimental Design and Method Selection:
The study involved the in vivo implementation of OCT imaging in the rat brain striatum using a high-definition OCT imaging catheter.
2：Sample Selection and Data Sources:
Two male 60-day-old rats (Rattus norvegicus, Albinus variation, Wistar) were used.
3：List of Experimental Equipment and Materials:
A
4：7-French diameter high-definition OCT imaging catheter (Dragonfly, St. Jude Medical, USA) and a mobile console (C7-XRTM, St. Jude Medical) for OCT image acquisition. Experimental Procedures and Operational Workflow:
Rats were anesthetized and placed in a stereotactic frame. Guide cannulas were implanted into the striatum to guide the OCT imaging catheter. Images were processed and compared with histological slices.
5：Data Analysis Methods:
Obtained images were compared with corresponding histologically stained sections to collect imaging samples.
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