研究目的
To determine the usefulness of dual-energy CT (DECT) iodine quantification to classify the focal thyroid lesions.
研究成果
DECT iodine quantification may have a potential role to determine which incidental thyroid nodule detected by CT examination would be recommended for further sonographic evaluation.
研究不足
1. The IC of thyroid lesions in contrast-enhanced CT is determined by intrinsic ICs and extrinsic ICs of injected contrast media, the latter being quite variable. 2. Restrictive inclusion of neck CT images under the same scanning protocol. 3. Retrospective ROI drawing by a radiologist knowing sonographic features and cytopathological results. 4. Only patients with PTCs were enrolled, not generalizable to other thyroid malignancies.
1：Experimental Design and Method Selection:
Retrospective study using DECT-derived iodine maps to quantify iodine concentration in focal thyroid lesions.
2：Sample Selection and Data Sources:
76 cytopathologically confirmed focal thyroid lesions from patients undergoing both neck ultrasound and CT examination.
3：List of Experimental Equipment and Materials:
Dual-layer detector DECT (IQon Spectral CT scanner; Philips Healthcare), contrast media (Omnipaque 300 mgI/mL, GE Healthcare; Pamiray 300 mgI/mL, Dongkook Pharm; Optiray 350 mgI/mL, Mallinckrodt Pharmaceuticals).
4：Experimental Procedures and Operational Workflow:
Drawing ROI on DECT-derived iodine maps, comparing IC_N and normalized IC_N between PTC, benign nodule, and cyst groups.
5：Data Analysis Methods:
Statistical analysis using SPSS software and pROC package of R.
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