研究目的
To study the influence of optical and geometric parameters on the spectral response of a fiber optic biosensor for sensitivity analysis and numerical optimization, aiming to improve performance by replacing the prism with an optical fiber.
研究成果
The numerical model effectively simulates the SPR response, showing that optimal performance is achieved with a metal layer thickness of 50 nm, sensitive area length of 5 mm, and core diameter of 300 μm. This configuration provides high sensitivity and precision for biosensing applications, demonstrating the feasibility of using optical fibers to replace prisms in SPR biosensors.
研究不足
The study is purely numerical and theoretical, lacking experimental validation. It focuses on specific parameters and may not account for all real-world variations or complexities in biosensor applications.
1：Experimental Design and Method Selection:
The study uses a numerical modeling approach based on a matrix formalism for multilayer media, implemented in MATLAB, to simulate the SPR response. It involves theoretical analysis of transmitted power and reflectivity.
2：Sample Selection and Data Sources:
Simulations are performed for a fiber optic biosensor detecting E. coli bacteria, with refractive indices ranging from 1.352 to 1.
3：352 to List of Experimental Equipment and Materials:
367.
3. List of Experimental Equipment and Materials: Optical fiber with core diameters of 100-500 μm, gold metal layer with thicknesses of 30-70 nm, and sensitive area lengths of 1-7 mm. No specific brands or models are mentioned.
4：Experimental Procedures and Operational Workflow:
The process includes calculating reflectivity and transmitted power using Fresnel coefficients and matrix methods, varying parameters such as core diameter, metal thickness, and sensitive length to observe effects on resonance curves.
5：Data Analysis Methods:
Sensitivity is calculated as the ratio of spectral shift to refractive index change (nm/RIU). Results are analyzed through plots of transmission, reflectivity, resonance wavelength, mid-height width, and sensitivity versus parameters.
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