研究目的
To construct a triple-responsive graphene oxide hybrid supramolecular hydrogel for controlled release applications, responding to NIR light, temperature, and pH stimuli.
研究成果
The constructed GO hybrid supramolecular hydrogels successfully exhibited responsiveness to NIR light, temperature, and pH, enabling controlled release of cargo molecules such as 5-FU. This multi-stimuli responsiveness makes them promising for advanced delivery systems, with potential applications in biomedicine. Future work should focus on in vivo studies and further tuning of material properties for enhanced performance.
研究不足
The study may have limitations in scalability for industrial applications, potential biocompatibility issues with graphene oxide, and the need for optimization in drug loading efficiency and release kinetics. Environmental factors like stability under long-term storage were not extensively addressed.
1：Experimental Design and Method Selection:
The study involved synthesizing a brush polymer (mPEG-QPDMAEMA) via quaternization, preparing supramolecular hydrogels through host-guest inclusion with α-cyclodextrin, and incorporating graphene oxide via electrostatic self-assembly. Methods included ATRP for polymerization, vial inversion for gel-sol transition, and UV-vis spectroscopy for drug release analysis.
2：Sample Selection and Data Sources:
Samples included synthesized polymers (P1, P2, P3) with varying quaternization degrees, α-cyclodextrin at concentrations of 60, 70, 80 mg/mL, and graphene oxide. Data were obtained from NMR, FT-IR, XRD, rheology measurements, and drug release experiments.
3：List of Experimental Equipment and Materials:
Equipment included Schlenk flasks, water baths, ultrasonicator, centrifuge, UV-vis spectrometer, rheometer, SEM, XRD, and NIR laser (808 nm, 1.0 W cm-2). Materials included mPEG, bromoacetyl bromide, DMAEMA, CuBr, Me6TREN, EBIB, THF, ethanol, α-cyclodextrin, graphene oxide, and 5-FU.
4：0 W cm-2). Materials included mPEG, bromoacetyl bromide, DMAEMA, CuBr, Me6TREN, EBIB, THF, ethanol, α-cyclodextrin, graphene oxide, and 5-FU.
Experimental Procedures and Operational Workflow:
4. Experimental Procedures and Operational Workflow: Synthesis of mPEG-Br and PDMAEMA, quaternization to form mPEG-QPDMAEMA, preparation of hydrogels by mixing with α-CD and GO, gelation incubation for 48 hours, measurement of gel-sol transition temperatures, NIR irradiation tests, and drug loading/release studies with pH and temperature variations.
5：Data Analysis Methods:
Data were analyzed using 1H NMR for structural confirmation, FT-IR for functional groups, XRD for crystallinity, rheology for viscoelastic properties, and UV-vis spectroscopy for drug release quantification. Statistical analysis involved comparing release profiles under different stimuli.
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