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Measurement of peripheral dose to pelvic region and associated risk for cancer development after breast intraoperative electron radiation therapy

DOI:10.1088/1361-6498/aafdc8 期刊:Journal of Radiological Protection 出版年份:2019 更新时间:2025-09-23 15:23:52
摘要: This study aimed to measure received dose to the pelvic region of patients during breast intraoperative electron radiation therapy (IOERT). Furthermore, we compared the findings with those of external beam radiation therapy. Finally, secondary ovary and uterus cancer risks following breast IOERT were estimated. In the current study, the received dose to the pelvic surface of 18 female patients during breast IOERT boost were measured by thermoluminescent dosimeter (TLD-100) chips. All patients were treated with 12 Gy given in a single fraction. To estimate the dose to the ovary and uterus of the patients, conversion coefficients for depth from surface dose were obtained in a Rando phantom. Given the received dose to the pelvic region of the patients, secondary ovary and uterus cancer risks following breast IOERT were estimated. The received doses to ovary and uterus surface of the patients were 0.260±0.155 mGy to 31.460±6.020 mGy and 0.485±0.122 mGy to 22.387±15.476 mGy, respectively. Corresponding intra-pelvic (ovary and uterus) regional doses were 0.012±0.007 mGy to 1.479±0.283 mGy and 0.027±0.001 mGy to 1.164±0.805 mGy, respectively. Findings demonstrated that the ratio of the received dose by pelvic surface to regional dose during breast IOERT was much less than external beam energies were 135.722±117.331 × 10-6 and 69.958±28.072 × 10-6, and for uterus were 17.342±10.583 × 10-6 and 2.971±3.604 × 10-6, respectively. According to our finding, the use of breast IOERT in pregnant patients can be considered as a safe radiotherapeutic technique, because the received dose to the fetus was lower than 50 mGy. Furthermore, IOERT can efficiently reduce the unnecessary dose to the pelvis region and lowers the risk of a secondary ovary and uterus cancer following breast irradiation.
作者: Seyed Rabie Mahdavi,Mahdieh Tutuni,Bagher Farhood,Shiva Ghasemi,Nahid Nafisi,Hamidreza Mirzaee,Soraya Ahmadi,Ahad Alizadeh
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To measure the peripheral dose to the pelvic region during breast intraoperative electron radiation therapy (IOERT), compare it with external beam radiation therapy, and estimate secondary cancer risks for ovary and uterus.

Breast IOERT results in lower peripheral doses to the pelvic region compared to external beam radiation therapy, with doses to the fetus below the safe threshold of 50 mGy, making it a safe option for pregnant patients. IOERT reduces unnecessary pelvic exposure and lowers secondary cancer risks for ovary and uterus. Future research should include measurements with shielding and assess other body regions.

Conversion coefficients for ovary and uterus doses were obtained for a specific applicator size (5 cm) and applied to all sizes (3 cm to 8 cm), which may not be fully accurate. The study did not use abdominal shielding aprons, and measurements were limited to the pelvic region; other body parts were not assessed.

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