研究目的
To measure the peripheral dose to the pelvic region during breast intraoperative electron radiation therapy (IOERT), compare it with external beam radiation therapy, and estimate secondary cancer risks for ovary and uterus.
研究成果
Breast IOERT results in lower peripheral doses to the pelvic region compared to external beam radiation therapy, with doses to the fetus below the safe threshold of 50 mGy, making it a safe option for pregnant patients. IOERT reduces unnecessary pelvic exposure and lowers secondary cancer risks for ovary and uterus. Future research should include measurements with shielding and assess other body regions.
研究不足
Conversion coefficients for ovary and uterus doses were obtained for a specific applicator size (5 cm) and applied to all sizes (3 cm to 8 cm), which may not be fully accurate. The study did not use abdominal shielding aprons, and measurements were limited to the pelvic region; other body parts were not assessed.
1:Experimental Design and Method Selection:
A prospective cohort study was conducted using in vivo dosimetry with thermoluminescent dosimeters (TLD-100) to measure surface doses on the pelvic region of patients during breast IOERT. Conversion coefficients for depth doses were derived from phantom studies using a Rando phantom. Secondary cancer risks were estimated using the BEIR VII model.
2:Sample Selection and Data Sources:
18 female patients with breast cancer, aged 24 to 66 years, treated with IOERT boost at a hospital in Iran. Data included patient demographics, treatment parameters (electron beam energy, applicator size), and BMI classifications.
3:List of Experimental Equipment and Materials:
TLD-100 dosimeter chips (Harshaw, USA), Rando phantom (Phantom Laboratory, NY, USA), LIAC mobile linear accelerator (Sordina IORT Technologies S.P.A.), plastic pockets for TLD wrapping.
4:Experimental Procedures and Operational Workflow:
TLD chips were calibrated and placed on the pelvic surface of patients during IOERT procedures. For each measurement, six TLD chips were used and averaged. Phantom measurements involved placing TLD chips at surface and depth (9 cm) to obtain conversion coefficients. Data were collected and analyzed statistically.
5:Data Analysis Methods:
Statistical analysis was performed using R software (version 3.4.1). Normality was assessed with Shapiro-Wilks test. Pearson or Spearman correlation coefficients, Mann-Whitney U, and Kruskal-Wallis tests were used for comparisons. Data reported as mean ± SD with significance at P < 0.05.
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