研究目的
To develop bi-functional Nd3+-doped Y2O3 nanoparticles that serve as both thermal sensors and heaters for applications in controllable photo-thermal therapy, utilizing multiple temperature sensing parameters in biological windows.
研究成果
Bi-functional Y2O3:Nd3+ nanoparticles were successfully developed, demonstrating effective thermal sensing and heating capabilities. Multiple sensing parameters were evaluated, with luminescence intensity ratio between electronic levels showing the highest thermal sensitivity. The nanoparticles achieved sub-degree temperature resolution and good repeatability, making them suitable for applications in photo-thermal therapy. Higher doping concentrations improved heating efficiency, with the 2 at.% sample showing the best performance.
研究不足
The study is limited to Nd3+-doped Y2O3 nanoparticles and may not generalize to other materials. Thermal sensing based on Stark sublevels is restricted to a narrower temperature range (123–573 K). High-resolution detection systems are required for accurate measurements of spectral line position and bandwidth, which could be a practical constraint. The heating efficiency is dependent on doping concentration and may not be optimal for all applications.
1：Experimental Design and Method Selection:
The study involved synthesizing Nd3+-doped Y2O3 nanoparticles using the combined Pechini-foaming technique to achieve uniform distribution and prevent agglomeration. Various temperature-dependent luminescence parameters (luminescence intensity ratio, spectral line position, line bandwidth) were analyzed for thermal sensing. Laser-induced heating was investigated using 808 nm excitation.
2：Sample Selection and Data Sources:
Nanoparticles with Nd3+ doping concentrations of 0.05 at.%, 1 at.%, and 2 at.% were prepared. Data were collected from photoluminescence spectra measured at temperatures ranging from 123 K to 873 K.
3：05 at.%, 1 at.%, and 2 at.% were prepared. Data were collected from photoluminescence spectra measured at temperatures ranging from 123 K to 873 K.
List of Experimental Equipment and Materials:
3. List of Experimental Equipment and Materials: Equipment included a Rigaku Miniflex II diffractometer for XRD, SUPRA 40VP WDS SEM for imaging, T64000 Raman Spectrometer for fluorescence characterization, 532 nm and 808 nm lasers for excitation, Symphony II and Synapse CCD detectors for signal measurement, and a Linkam THMS 600 heating stage for temperature control. Materials included Y2O3, Nd2O3, nitric acid, aluminum nitrate, citric acid, potassium chloride, ethylene glycol, and NaOH.
4：Experimental Procedures and Operational Workflow:
Synthesis involved dissolving oxides in nitric acid, adding reagents, heating to form chelate complexes, polymer gel formation with ethylene glycol, calcination at 1000 °C, washing with NaOH, and drying. For measurements, samples were excited with lasers, and fluorescence signals were detected with CCD detectors. Temperature was controlled using the heating stage, with a 3-minute stabilization period before measurements.
5：Data Analysis Methods:
Data were analyzed using Boltzmann fitting for luminescence intensity ratios, theoretical expressions for spectral line position and bandwidth, and statistical methods for thermal sensitivity and uncertainty calculations. Deconvolution procedures were used for precise line position and bandwidth determination.
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