研究目的
To review the applications of nanostructures in wide-field, label-free super resolution microscopy, focusing on hyperlens, microsphere, and nanowire ring illumination microscopy, and discuss bottlenecks and solutions.
研究成果
Nanostructures such as hyperlenses, microspheres, and nanowire ring illumination enable label-free, wide-field super-resolution microscopy by detecting high spatial frequency information. Key improvements in resolution, SNR, and FOV are possible, but challenges remain in SNR, FOV, and real-time imaging. Future directions include using gain materials in hyperlenses, improving microsphere positioning, and integrating scanning systems for faster imaging in NWRIM.
研究不足
The techniques are limited to surface detection without deep three-dimensional imaging capabilities. Hyperlenses have trade-offs between magnification and imaging speed, limited working wavelengths, and fabrication challenges. Microsphere techniques have small field of view and positioning difficulties. NWRIM requires multiple frames for full spatial frequency detection, which can be time-consuming.
