1：Experimental Design and Method Selection:

The study employed the Turbiscan optical analyzer based on multiple light scattering technology to monitor the physical stability of ritonavir colloidal dispersions. The solvent shift method was used to prepare dispersions, and a two-step kinetic model was applied to analyze coalescence.

2：Sample Selection and Data Sources:

Ritonavir was used as the model compound, with colloidal dispersions prepared at different concentrations (70 μg/mL, 100 μg/mL, 83 μg/mL, 113 μg/mL), temperatures (25°C, 37°C), solvent compositions (1% ethanol, 5% ethanol), and with various polymer additives (e.g., PAA, PEG, HPMCAS, PVP, PVPVA, HPMC).

3：List of Experimental Equipment and Materials:

Equipment included Turbiscan Tower (Formulaction), Zetasizer Nano ZS (Malvern), μDiss Profiler (PION), water bath (Caron), rotary evaporator (Buchi), DSC Q2000 (TA Instruments), TGA Q5000 (TA Instruments), syringe pump (Harvard Apparatus), and various syringes and vials. Materials included ritonavir, ethanol, methanol, phosphate buffer, polymers from Sigma-Aldrich, Ashland, Dow, and Avantor.

4：Experimental Procedures and Operational Workflow:

Dispersions were prepared by injecting ritonavir ethanol solutions into aqueous buffer with stirring. Turbiscan measurements were taken at 1-minute intervals for an hour, starting 60 seconds after solvent shift. DSC and TGA were used to determine wet glass transition temperature and moisture content.

5：Data Analysis Methods:

Mean transmission signals from Turbiscan were analyzed using exponential decay models. Particle size was measured with DLS. Statistical analysis included standard deviations and curve fitting.