研究目的
To describe the imaging findings of a perifoveal exudative vascular anomalous complex (PEVAC) lesion in a patient with co-existent diabetic retinopathy.
研究成果
The case confirms that PEVAC can co-exist with diabetic retinopathy and is characterized by specific imaging features and non-responsiveness to standard treatments like anti-VEGF therapy. This highlights the importance of multimodal imaging for accurate diagnosis and suggests that PEVAC may occur in patients with other retinal pathologies, necessitating further research into its pathogenesis and management.
研究不足
This is a single case report, which limits generalizability. The study does not include a control group or statistical analysis. The response to treatment was poor, indicating potential resistance, but the underlying mechanisms are not fully understood.
1：Experimental Design and Method Selection:
This is a case report study involving multimodal imaging to characterize a PEVAC lesion in a patient with diabetic retinopathy. Methods include clinical examination and imaging techniques such as optical coherence tomography (OCT), fluorescein angiography, indocyanine green angiography, and OCT-angiography.
2：Sample Selection and Data Sources:
A single 70-year-old male patient with a history of diabetes mellitus and diabetic retinopathy was selected based on clinical presentation and referral to the retina clinic.
3：List of Experimental Equipment and Materials:
Instruments used include slitlamp biomicroscopy with +78 D lens, Spectralis (Heidelberg Engineering) for OCT and indocyanine green angiography, and Topcon AngioVue for OCT-angiography. Materials include intravitreal injections of anti-VEGF agents, steroids, and focal laser photocoagulation equipment.
4：Experimental Procedures and Operational Workflow:
The patient underwent initial clinical evaluation, followed by multimodal imaging sessions. Treatment involved multiple intravitreal injections and laser therapy over 10 months, with follow-up visits and repeated imaging to monitor response.
5：Data Analysis Methods:
Imaging data were analyzed qualitatively to identify characteristic features of PEVAC and diabetic retinopathy, and visual acuity measurements were recorded over time.
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