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β-Cyclodextrin–Hyaluronic Acid Polymer Functionalized Magnetic Graphene Oxide Nanocomposites for Targeted Photo-Chemotherapy of Tumor Cells
摘要： A multifunctional targeted drug delivery platform (CDHA–MGO) has been successfully constructed by grafting β-cyclodextrin–hyaluronic acid polymers (CDHA) to Fe3O4–graphene oxide (MGO). The obtained CDHA–MGO nanocomposite has good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. The β-cyclodextrin-hyaluronic acid polymers ef?caciously enhance the doxorubicin (DOX) loading amount up to 485.43 mg·g?1. Meanwhile, the Fe3O4–graphene oxide provides a facile photothermal response mechanism to handle the NIR-triggered release of DOX in weak acidic solvent environments. Signi?cantly, the DOX-loaded nanocomposite (DOX@CDHA–MGO) has displayed CD44 receptor-mediated active targeting recognition and chemo-photothermal synergistic therapy of hepatoma cells. These ?ndings suggest that the as-prepared drug delivery platform would be of valuable potential for cancer-targeted photo-chemotherapy.
关键词： β-cyclodextrin,magnetic graphene oxide,photo-chemotherapy,near-infrared,hyaluronic acid
更新于2025-09-19 17:15:36
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Fast responsive photo-switchable dual-color fluorescent cyclodextrin nanogels for cancer cell imaging
摘要： Photo-switchable dual-color fluorescent nanogels were fabricated via nanoprecipitation in aqueous solution. The spiropyran-modified β-cyclodextrin (β-CD-SP) and 4-amino-7-nitro-1,2,3-benzoxadiazole (NBDNH2) were encapsulated into nanogels in the presence of 1,6-hexamethylene diisocyanate (HMDI). In the nanogels, spiropyran moiety acted as fluorescence molecule acceptors under the irradiation of UV or visible light to quench or recover the fluorescence of the NBDNH2 to achieve reversible dual-color fluorescence. The feed ratio of the two fluorophores played vital role on the energy transfer efficiency (E) of the nanogels, and the results showed that high E (90.7%) can be achieved when the feed ratio of NBDNH2/β-CD-SP is 1:2 (mol/mol). In addition, the nanogels can maintain good photo-switchable fluorescent behavior as long as 5 weeks. With rapid photo-responsiveness (within 60 s), good reversibility, long-term stability, and excellent cytocompatibility, the as-prepared nanogels have been successfully applied to photo-switchable dual-color fluorescent imaging in cancer cell.
关键词： Photo-switchable,Spiropyran,Cyclodextrin,Nanogel
更新于2025-09-19 17:15:36
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The construction and modulation of photoelectric functional hierarchical materials based on ionic self-assembly
摘要： The photoelectric functional hierarchical materials have been successfully prepared by the simple ionic self-assembly (ISA) strategy from the cationic ferrocenyl surfactant, 16-alkyl (ferrocenyl-methyl)ammonium bromide (Fc16AB) and the anionic alizarin red (AR). The obtained complexes exhibited multiple stimuli-responsive switching behaviour triggered by β-cyclodextrin (β-CD) inclusion, redox species, and pH. The switching mechanism corresponding to each stimulus was studied in detail. Moreover, the fluorescent intensity of binary complexes could be modulated by the concentration of Fc16AB and redox of ferrocene part. The fluorescence switching mechanism upon redox stimulus was studied in detail. Both the complexes fabrication and transition mechanisms were found to be controlled by the inclusion equilibrium and the cooperative binding of non-covalent interactions, including the electrostatic interactions, π-π stacking, and amphiphilic hydrophobic association. This work provides a deep understanding of electro-photo molecular switching device.
关键词： Hierarchical materials,pH,Redox species,Stimuli-responsive,β-Cyclodextrin (β-CD) inclusion,Ionic self-assembly
更新于2025-09-19 17:15:36
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A novel disposable sensor based on gold digital versatile disc chip modified with graphene oxide decorated with Ag nanoparticles/β-cyclodextrin for voltammetric measurement of naproxen
摘要： A novel homemade disposable electrode made from gold digital versatile disc (G-DVD) and it was modified with graphene oxide decorated with Ag nanoparticles and β-cyclodextrin (AgNPs@GO-β-CD) for quantitative measurement of naproxen (NAP) in solution. Cyclic voltammetry and differential pulse voltammetry were used to evaluate the analytical response of the modified gold-DVD electrode to the NAP molecules. The nanohybrid which used in fabrication of the electrode, showed an excellent electrocatalytic activity towards oxidation of NAP. The calibration plot was linear within the concentration range of 0.4 μM to 80 μM of NAP molecules. The limits of detection and quantification were achieved as 0.023 μM (S/N = 3) and 0.08 μM (S/N = 10), respectively. Also, the RSDs were found to be 2.5% for 5 parallel experiments with the separate similar electrodes and 3.2% for 5 successive measurements with one electrode. The proposed electrochemical sensor, was successfully applied for measurement of NAP in real samples.
关键词： β-cyclodextrin,Gold disc,DVD,Ag nanoparticles,Naproxen,Graphene oxide
更新于2025-09-19 17:15:36
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Chiral differentiation of <scp>d</scp> - and <scp>l</scp> -isoleucine using permethylated β-cyclodextrin: infrared multiple photon dissociation spectroscopy, ion-mobility mass spectrometry, and DFT calculations
摘要： Chiral di?erentiation of protonated isoleucine (Ile) using permethylated b-cyclodextrin (perCD) in the gas-phase was studied using infrared multiple photon dissociation (IRMPD) spectroscopy, ion-mobility, and density functional theory (DFT) calculations. The gaseous protonated non-covalent complexes of perCD and D-Ile or L-Ile produced by electrospray ionization were interrogated by laser pulses in the wavenumber region of 2650 to 3800 cm?1. The IRMPD spectra showed remarkably di?erent IR spectral features for the D-Ile or L-Ile and perCD non-covalent complexes. However, drift-tube ion-mobility experiments provided only a small di?erence in their collision cross-sections, and thus a limited separation of the D- and L-Ile complexes. DFT calculations revealed that the chiral distinction of the D- and L-complexes by IRMPD spectroscopy resulted from local interactions of the protonated Ile with perCD. Furthermore, the theoretical results showed that the IR absorption spectra of higher energy conformers (by B13.7 kcal mol?1) matched best with the experimentally observed IRMPD spectra. These conformers are speculated to be formed from kinetic-trapping of the solution-phase conformers. This study demonstrated that IRMPD spectroscopy provides an excellent platform for di?erentiating the subtle chiral di?erence of a small amino acid in a cyclodextrin-complexation environment; however, drift-tube ion-mobility did not have su?cient resolution to distinguish the chiral di?erence.
关键词： chiral differentiation,ion-mobility mass spectrometry,permethylated β-cyclodextrin,IRMPD spectroscopy,DFT calculations,isoleucine
更新于2025-09-19 17:15:36
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One-step preparation of single-layered graphene quantum dots for the detection of Fe3+
摘要： Single-layer graphene quantum dots are highly desirable while their facile and controllable preparations remain challenging. Herein, single-layered graphene quantum dots (sl-GQDs) were developed via a facile one-step hydrothermal synthesis, with citric acid and β-cyclodextrin (CD) as starting materials. The sl-GQDs decorated with CD molecules emit green fluorescence with a quantum yield of 5.34%, and exhibit a good response exclusively to ferric ions for their structural oxygenous groups. The linear range of the proposed sensor for ferric ions was found in a wide concentration range of 0-85 μM. The detection limit is about 0.26 μM. The sl-GQDs based sensing platform also demonstrates its feasibility in real water sample analysis with recoveries of 93.8%-101.5%.
关键词： One-step preparation,β-cyclodextrin,Fluorescence sensing,Single-layered graphene quantum dots,Ferric ion
更新于2025-09-19 17:13:59
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Pharmacokinetic Properties of Fluorescently Labelled Hydroxypropyl-Beta-Cyclodextrin
摘要： 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is utilized in the formulation of pharmaceutical products and recently orphan designation was granted for the treatment of Niemann–Pick disease, type C. The exact mechanism of HPBCD action and side effects are not completely explained. We used fluorescently labelled hydroxypropyl-beta-cyclodextrin (FITC-HPBCD) to study its pharmacokinetic parameters in mice and compare with native HPBCD data. We found that FITC-HPBCD has fast distribution and elimination, similar to HPBCD. Interestingly animals could be divided into two groups, where the pharmacokinetic parameters followed or did not follow the two-compartment, first-order kinetic model. Tissue distribution studies revealed, that a significant amount of FITC-HPBCD could be detected in kidneys after 60 min treatment, due to its renal excretion. Ex vivo fluorescent imaging showed that fluorescence could be measured in lung, liver, brain and spleen after 30 min of treatment. To model the interaction and cellular distribution of FITC-HPBCD in the wall of blood vessels, we treated human umbilical vein endothelial cells (HUVECs) with FITC-HPBCD and demonstrated for the first time that this compound could be detected in the cytoplasm in small vesicles after 30 min of treatment. FITC-HPBCD has similar pharmacokinetic to HPBCD and can provide new information to the detailed mechanism of action of HPBCD.
关键词： endocytosis,pharmacokinetics,fluorescence,hydroxypropyl-beta-cyclodextrin,HUVECs
更新于2025-09-16 10:30:52
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Magnetic Supramolecular Nanofibers of Gold Nanorods for Photothermal Therapy
摘要： Molecular aggregation triggered by physical and chemical stimuli and based on multiple noncovalent interactions has immense potential utility for modeling and mimicking biological systems and for the diagnosis and treatment of degenerative diseases. Herein the preparation, properties, and biological activities of a new type of organic–inorganic hybrid supramolecular nanofiber composed of gold nanorods, mitochondrion-targeting-peptide-coated iron oxide nanoparticles, and hyaluronic-acid (HA)-modified β-cyclodextrin is reported. These photothermal nanofibers, which grew along the direction of the geomagnetic field, induced severe mitochondrial damage in human adenocarcinoma cells (A549); and, more strikingly, the nanofibers greatly suppress metastasis and clear A549 cells in tumor-bearing mice upon irradiation with a near-infrared laser. The ability to recruit HA-receptor-expressing tumor cells and to target mitochondria, as well as the high photothermal conversion efficiency imparted by the gold nanorods, makes these supramolecular nanofibers a promising nanotherapy for cancer in general and metastasis-related malignancy in particular.
关键词： gold nanorods,supramolecular nanofibers,photothermal therapy,cyclodextrin,tumor metastasis
更新于2025-09-10 09:29:36
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Rose Bengal Incorporated to α-Cyclodextrin Microparticles for Photodynamic Therapy against the cariogenic microorganism Streptococcus mutans
摘要： Rose Bengal@α-cyclodextrin (RB@α-CD) microparticles (μPs) were prepared and the RB inclusion in α-CD was experimentally demonstrated through infrared, UV-VIS absorption spectroscopy and cyclic voltammetry. The RB inclusion in α-CD was theoretically investigated using classical molecular mechanics calculations, the simulation results showing that RB can be included in both the narrow and wide apertures of the α-cyclodextrin ring with configurations exhibiting average binding energies of about 27 kcal.mol-1. The prepared RB@α-CD microparticles were characterized through Scanning Electron Microscopy (SEM) and it was demonstrated that they are highly efficient in the photodynamic therapy against a Streptococcus mutans (the main bacteria of cariogenic dental plaque) suspension, as a concentration of RB@α-CD μPs 10 times smaller than the usual concentration of pure RB is still capable to produce significant antibacterial activity.
关键词： antibacterial activity,molecular interaction simulations,Rose Bengal,photodynamic therapy,α-cyclodextrin microparticles
更新于2025-09-10 09:29:36
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A highly efficient chiral sensing platform for tryptophan isomers based on a coordination self-assembly
摘要： Construction of convenient and effective method for enantiomer identification is of vital significance for biochemistry and medical science. Herein, we design an effective sensor for chiral recognition of tryptophan (Trp) enantiomers, and self-assembly of Cu2+-modified β-cyclodextrin on poly-L-arginine/multi-walled carbon nanotubes (Cu-β-CD/PLA/MWCNTs) is studied. Meanwhile, Cu2+ acts as a cap to prevent the release of the high energy water and compel Trp enantiomer into the smaller opening of β-cyclodextrin. Recognition of L-Trp is accomplished by the formation of hydrogen bonds between the amino of L-Trp and the the high energy water confined in cavity of Cu-β-CD. Compared with D-Trp, the sensor exhibits favorable chiral recognition toward L-Trp with a separation coefficient of 3.37. And the chiral sensor presents admirable enantiomers determination with excellent sensitivity, providing a good linear correlation in the range of 1×10-6 M~5.5×10-5 M, and the detection limit can reach 3.3×10-7 M (S/N=3). Besides, the proposed sensor has been able to predict the percentage of D-Trp in the racemic mixture, suggesting its potential applications in the enantiomer recognition field.
关键词： Chiral recognition,Cu-β-cyclodextrin,Tryptophan enantiomers,self-assembly
更新于2025-09-09 09:28:46