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A new multi-analyte fluorogenic sensor for efficient detection of Al <sup>3+</sup> and Zn <sup>2+</sup> ions based on ESIPT and CHEF features
摘要： The fluorogenic chemosensor 3-(((2-hydroxy-4-methylphenyl)imino)methyl)-[1,10-biphenyl]-4-ol (H2L) efficiently detects Zn2+ and Al3+ ions and subsequently fluoride ion in methanol–water (4/1, v/v, pH = 7.2) solution. The probe itself is non-emissive but upon treatment with Al3+ and Zn2+, it exhibits high fluorescence emission at two different wavelengths of 546 nm and 529 nm, respectively. Both excited-state intramolecular proton transfer (ESIPT) and chelation enhanced fluorescence (CHEF) processes play important roles in the enhancement of fluorescence intensity. Chelation of Zn2+ and Al3+ with the probe (H2L) inhibits CQN isomerization and ESIPT which consequently enhances the emission intensity. The emission intensity of H2L–Al3+ is selectively quenched upon titration with F- anions. The structure of the probe is confirmed by the single crystal X-ray diffraction method. The electronic structure and sensing mechanism of the probe (H2L) are supported by density functional theory (DFT) and time-dependent density functional theory (TDDFT).
关键词： Zn2+ detection,fluoride detection,CHEF,fluorogenic sensor,ESIPT,Al3+ detection
更新于2025-11-19 16:46:39
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A colorimetric, ultraviolet absorption and fluorescence three-signal probe based on bis-carbazole for Al3+ detection and the application in cell imaging
摘要： A novel Schiff-base, [9-(2-Chloro-ethyl)-9H-carbazol-3-yl-methylene]-(9-ethyl-9H-carbazol-3-yl)-amine (CECA) was designed and synthesized, which was highly selective and sensitive for the detection of Al3+ by colorimetric, ultraviolet absorption and fluorescence three-signal methods. The detection limit was evaluated to be as low as 74 nmol/L for the ultraviolet absorption method and 19 nmol/L for fluorometric method. These three methods could determine qualitatively and quantitatively the concentrations of Al3+ and been used in different conditions. The mechanism was explored that the double bond (C=N) of CECA was broken to form the carbazole aldehyde and carbazole amine complex accompanied by fluorescence enhancement by the Job's plot, 1H NMR, the electrospray ionization mass spectra (EI-MS) and fluorescence methods. More significantly, the fluorescence imaging showed that CECA could detect Al3+ in living cells.
关键词： Schiff base,Al3+,Detection,Imaging,Three-signal
更新于2025-11-14 15:29:11
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An efficient new dual fluorescent pyrene based chemosensor for the detection of bismuth (III) and aluminium (III) ions and its applications in bio-imaging
摘要： A new simple pyrene based schiff base chemosensor 1 (nicotinic acid pyren-1-ylmethylene-hydrazide) has been constructed and is prepared from 1-pyrenecarboxaldehyde and nicotinic hydrazide. Notably, the chemosensor 1 exhibited remarkable colour changes while in the presence of trivalent metal ions like Bi3+ & Al3+ ion in DMSO-H2O, (1:1 v/v, HEPES = 50 mM, pH = 7.4). The UV-Vis spectral investigation of chemosensor 1 showed that the maximum absorption peak appeared at 378 nm. In emission studies, chemosensor 1 develops weak fluorescence, while upon the addition of Bi3+ and Al3+ ions, it exhibits an enhancement of fluorescence intensity. Nevertheless, rest of metal ions have no changes in the emission spectra. The association constant of chemosensor 1 for binding to Bi3+ & Al3+ system had a value of 1.27 × 104 M-1 and 1.53 × 104 M-1. The detection limits were 0.12 μM for Bi3+ and 0.17 μM for Al3+ respectively. The overall results reveal that chemosensor 1 can act as a dual-channel, highly selective, and sensitive probe for Bi3+ and Al3+ ions. Moreover, the fluorescence imaging of chemosensor 1 was applied in RAW 264.7 cell line and cytotoxicity assay prove that this chemosensor 1 is non-toxic as well as highly biocompatible.
关键词： Pyrene Schiff base,Spectroscopic studies,Live cell imaging,PET,Bi3+ and Al3+ detection
更新于2025-09-19 17:15:36
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Development of 1,2- and 1,3-Ketohydrazones Derived Rhodamine Chromophores Sensitive to Metal Ions and pH
摘要： New Rhodamine derivatives were developed from ketohydrazones. 2,4-Pentanedione and 1,3-cyclohexanedione condensation of rhodamine-hydrazine afforded a stable enol hydrazone and enamine rhodamines via equilibrium shifts. Enamine rhodamine exhibited strong pH sensitivity. 2-Cyclohexanedione rhodamine emitted a strong fluorescence as a selective Al3+ sensing probe. The binding constants of the enol hydrazone rhodamine were 2.0 × 104 M?1 (Al3+) and 5.4 × 104 (Cu2+).
关键词： Rhodamine Chemosensor,Al3+ Detection,Ketohydrazone,Fluorescence
更新于2025-09-09 09:28:46