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Blue Electrogenerated Chemiluminescence from Halide Perovskite Nanocrystals
摘要： Electrogenerated chemiluminescence (ECL) has been extensively used in ultrasensitive electroanalysis because it can be generated electrochemically without using expensive optics and light sources. Visible ECL emission can be obtained with a reasonable quantum yield and stability. Blue ECL is rare and often suffers from stability and poor quantum efficiency. Blue ECL emission at 473 nm from organometallic halide perovskite nanocrystals (PNCs), CH3NH3PbCl1.08Br1.92, is reported here for the first time using tripropylamine (TPrA) as co-reactant. The blue ECL emission peak resembles its photoluminescence peak position. In addition to this blue emission peak, the ECL spectra of CH3NH3PbCl1.08Br1.92 PNCs also showed a broad ECL peak at 745 nm. Generation of the second ECL peak at 745 nm from CH3NH3PbCl1.08Br1.92 PNCs was can be explained by the existence of surface trap states on as-synthesized PNC due to incomplete surface passivation. Halide anion tunability of ECL emission from CH3NH3PbX3 (X: Cl, Br, I) PNCs is also demonstrated. The fluorescence microscopy image of single PNC and stability of selected single PNCs are presented in this with simultaneous acquisition of fluorescence spectra using 405-nm laser excitation. The photoluminescence (PL) decay was described by PL lifetime (τ) of 1.2 ns. The effect of the addition of surfactants (oleic acid and n-octylamine) on the fluorescence intensity and stability of CH3NH3PbCl1.08Br1.92 PNCs is also discussed.
关键词： Surfactants,Blue light emission,ECL (electrogenerated chemiluminescence),Photoluminescence (PL),Perovskite nanocrystals (PNCs),Photoluminescence quantum yield (PLQY)
更新于2025-09-23 15:23:52
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Cataluminescence sensor for highly sensitive and selective detection of iso-butanol
摘要： In this paper, a gaseous sensor was described for detection of iso-butanol on the basis of its strong cataluminescence (CTL) emission on nano-MgO surface. The sensor showed high sensitivity and specificity to iso-butanol with response time less than 1 s and recovery time less than 18 s. A good linearly relationship between CTL intensity and the concentration of iso-butanol was observed in the range of 7.6 to 3350 mg/m3 (r = 0.9992), the limit of detection was 2.5 mg/m3. The proposed CTL sensor exhibits good specificity to iso-butanol against other compounds including common alcohols. The possible reaction paths of iso-butanol on the MgO surface were investigated in detail. Results shows that the hydrogen atom abstraction of iso-butanol to form β-Riso following consumption via Waddington mechanism possible is a major reaction channel for CTL emission. The sensor was applied to analyze iso-butanol in spiked samples, satisfactory recoveries were obtained in the range of 96.6 to 112.8% and the RSDs were 5.0 to 10.1%, indicating that the proposed sensor is a promising candidate for rapid analysis of iso-butanol.
关键词： Cataluminescence,Nanosized MgO,Chemiluminescence,Iso-butanol,Sensor
更新于2025-09-23 15:21:21
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Ratiometric Electrogenerated Chemiluminescence Cytosensor Based on Conducting Polymer Hydrogel Loaded with Internal Standard Molecules
摘要： A sensitive and reliable bimodal electrochemiluminescent (ECL) system based on CdTe Quantum Dots (QDs) and luminol as double luminophores is constructed. CdTe QDs tagged with the aptamer (CdTe-Apt 2) of cancer cells are used as the detection signal, while luminol molecules are used as internal standards. The electrodeposited polyaniline based conducting polymer hydrogel (CPH) on the electrode surfaces improves the biocompatibility and conductivity of the sensing interfaces effectively. Furtherly, electron transfer is probably much easier when luminol and coreactant potassium persulfate (K2S2O8) immobilized in the CPH compared to that in solution. Cancer cells are captured to the electrode surface by another aptamer linked to the Au nanoparticles immobilized in the CPH through Au-S bonds. In the developed bimodal ECL system, internal standard method is used to quantify cancer cells by comparing the differences in sensitivity of the double-peak ECL signals with that of target analytes. The internal standard method of ECL strategy can provide very accurate detection results in complex environment because interferences in the system can be eliminated through the self-calibration of two emission spectra. A linear relation is found based on the ?ECLCdTe/?ECLluminol against the concentration of cancer cells within 100 to 6500 cells mL-1 under optimized conditions. The developed ratiometric ECL cytosensor with internal standard can significantly improve the accuracy and reliability of cell assay in complex biological media, demonstrating promising applications in healthcare monitoring and clinical diagnostics.
关键词： Cytosensor,Electrogenerated Chemiluminescence,Internal standard method,Conducting Polymer Hydrogel,Cancer cells
更新于2025-09-23 15:21:21
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Surface-plasmon-coupled chemiluminescence amplification of silver nanoparticles modified immunosensor for high-throughput ultrasensitive detection of multiple mycotoxins
摘要： A novel surface-plasmon-coupled chemiluminescent immunosensor was developed for the detection of multiplex mycotoxins with ultrahigh sensitivity, high throughput and simplicity. The immunosensor was constructed by immobilizing carboxyl modified silver nanoparticles (AgNPs) and bovine serum albumin combined antigens sequentially on the glass chip modified with amino groups. The optical properties of AgNPs could amplify the chemiluminescence (CL) generated on the chip through the surface plasmon resonance phenomenon. Using a competitive immunoassay, the CL signals from all the sensing sites on the chip were collected simultaneously by a charge-coupled device for ultrasensitive analysis of multiple mycotoxins. Citrinin, aflatoxin B1 and ochratoxins A were selected as model analytes. Under optimal conditions, the surface-plasmon-coupled chemiluminescent immunosensor-based method presented wide linear ranges over 4 orders of magnitude and much lower limits of detection than previous work. The assay results of mycotoxins in red yeast rice samples using the proposed method were in good agreement with that using the liquid chromatography-mass spectrometry method. Its high selectivity, high throughput, acceptable stability and accuracy showed broad prospects in mycotoxin monitoring and evaluation of safety on Traditional Chinese Medicine.
关键词： Immunosensor array,Signal amplification,Silver nanoparticle,Multiplex immunoassay,Mycotoxins,Surface-plasmon-coupled chemiluminescence
更新于2025-09-23 15:21:01
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Electrogenerated Chemiluminescence and Spectroelectrochemistry Characteristics of Blue Photoluminescence Perovskite Quantum Dots
摘要： Lead-based perovskite MAPbX3 (MA= CH3NH3, X=Cl and Br) has shown great potential benefits to advance modern optoelectronics and clean energy harvesting devices. Poor structural stability is one of the major challenges of MAPbX3 perovskite materials to overcome to achieve desired device performance. Here we present the electrochemical stability study of CH3NH3PbCl1.08Br1.92 quantum dots (QDs) by electrogenerated chemiluminescence (ECL) and photoluminescence (PL) spectroelectrochemistry methods. Electrochemical anodization of pristine MAPbX3 QD film results in the disproportionate loss of methylammonium and halide ions (X=Cl and Br). ECL efficiency and stability of perovskite QDs in the presence of co-reactant tripropyl amine (TPrA) can be greatly improved after being incorporated into a polystyrene (PS) matrix. Mass spectrum and X-ray photoelectron spectroscopy (XPS) measurements are used to provide chemical composition variation details of QDs, responsible for the ECL and PL characteristics (e.g., wavelength redshift) of perovskite QDs in an electrochemical cell.
关键词： quantum dots (QDs),Perovskite,Blue light emission,nanocrystals,polystyrene (PS),electrogenerated chemiluminescence (ECL),photoluminescence (PL)
更新于2025-09-23 15:21:01
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S, N-doped carbon quantum dots enhanced Luminol-Mn(IV) chemiluminescence reaction for detection of uric acid in biological fluids
摘要： Herein, S, N doped carbon quantum dots (S, N- CQDs) were prepared by a simple hydrothermal method and characterized by transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared (FTIR) analysis. The influence of as-prepared CQDs was studied on the luminol- Mn(IV) CL reaction. The results indicated that S, N-CQDs remarkably increase the CL intensity of this reaction (about 13 fold). Furthermore, it was found that the CL intensity of S,N-CQDs–luminol-Mn(IV) system was significantly declined by uric acid. We exploited the amplified CL system to design a novel probe for the detection of uric acid. The CL intensity of S,N-CQDs–luminol-Mn(IV) reaction was proportional to the logarithm of uric acid concentration in the range of 0.05 to 1.5 μM, with a limit of detection of 17 nM. Based on these results, a sensitive and straightforward CL method was developed for the analysis of uric acid in biological fluids with satisfactory results.
关键词： Uric acid,sulfur-nitrogen doped carbon quantum dots,Chemiluminescence,Mn (IV)
更新于2025-09-23 15:19:57
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Efficacy of light based detection systems for early detection of oral cancer and oral potentially malignant disorders: Systematic review
摘要： Background: Earlier detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) is essential for dental professionals to improve patient survival rates. The aim of this systematic review is to to evaluate the effectiveness of devices that utilise the principles of chemiluminescence and tissue autofluorescence as adjuncts in the detection of OSCC and OPMD. Material and Methods: The electronic retrieval systems and databases searched for relevant articles were PubMed [MEDLINE] and Science direct. The search was for limited articles published in English or with an English abstract and articles published during the period from January 2005 to April 2014. Clinical trials utilized ViziLite, Microlux TM/DL and Visual Enhanced Light scope (VELscope) for early detection of OPMD and OSCC. Results: Twenty primary studies published satisfied our criteria for selection - 10 utilised chemiluminescence and 10 tissue autofluorescence. Senstivity of Vizilite for detecting OSCC nad OPMD ranged from 77.1 % to 100% and specificity was low that ranged from 0% to 27.8%.Most have shown that chemiluminescence increases the brightness and margins of oral mucosal white lesions and thus assist in identification of mucosal lesions not considered under Conventional visual examination. However, it preferentially detects leukoplakia and may fail to spot red patches. Clinical trials demonstrated that sensitivity of VELscope in detecting malignancy and OPMD ranged from 22 % to 100 % and specificity ranged from 16 % to 100%. Most studies concluded that VELscope can help the experienced clinician to find oral precursor malignant lesions. But it couldnot differentiate between dysplasia and benign inflammatory conditions. Conclusions: Both devices are simple, non-invasive test of the oral mucosa but are suited for clinicians with sufficient experience and training. More clinical trials in future should be conducted to establish optical imaging as an efficacious adjunct tool in early diagnosis of OSCC and OPMD.
关键词： Oral cancer,early diagnosis,potentially malignant disorders,VELscope,chemiluminescence,ViziLite plus,tissue autofluorescence
更新于2025-09-19 17:15:36
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Molecular basis of the chemiluminescence mechanism of luminol
摘要： Light emission of luminol is probably one of the most popular chemiluminescence reactions due to its use in forensic science, recently displaying promising applications on the treatment of cancer in deep tissues. The mechanism is however very complex and distinct possibilities have been proposed. By efficiently combining DFT and CASPT2 methodologies, we have studied the chemiluminescence mechanism in three steps, (i) luminol oxygenation to generate the chemiluminophore, (ii) chemiexcitation step, and (iii) generation of light emitter. The findings demonstrate that luminol double deprotonated dianion activates molecular oxygen, that diazaquinone is not formed, and that the chemiluminophore is formed via concerted addition of oxygen and concerted elimination of nitrogen. The peroxide bond in comparison to other isoelectronic chemical functionalities (-NH?NH-, -N??N?-, and -S?S-) is found to have the best chemiexcitation efficiency, which allow to rationalize the oxygenation requirement and establishes general design principles for the chemiluminescence efficiency. Electron transfer from the aniline ring to the OO bond promotes the excitation process creating an excited state which is not the chemiluminescence species. To produce the light emitter, a proton transfer between the amino and carbonyl groups must occur, which is shown to require high localized vibrational energy during the chemiexcitation.
关键词： chemiexcitation efficiency,conical intersections,CASPT2,chemiluminescence,luminol
更新于2025-09-19 17:15:36
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Principles, mechanisms, and application of carbon quantum dots in sensors: a review
摘要： The Carbon quantum dots (CQDs) as an emerging class of quantum dots (QDs) with advantages such as good photoluminescence (PL) properties, easy synthesis routes, economical synthesis, cheap starting materials, water-solubility, low level of toxicity, chemical stability, and easy functionalization have received great attention during recent years. The CQDs have been used in versatile sensor applications. The CQDs sensors could be ultimately sensitive, and the limit of detection (LOD) for these sensors can reach the nanomolar, picomolar or even femtomolar ranges. The CQDs-based sensors and biosensors work with different mechanisms including fluorescence quenching, static quenching, dynamic quenching, energy transfer, inner filter effect (IFE), photo-induced electron transfer (PET), and fluorescence resonance energy transfer (FRET). The CQDs-based sensors and biosensors have been applied for detection of different species such as metal ions, acids, proteins, biothiols, polypeptides, DNA and miRNA, water pollutants, hematin, drugs, vitamins, and other chemicals. It seems that the CQDs-based sensors and biosensors are promising candidates for high performance and yet accurate sensors in different areas. In this review, the CQDs are introduced, and the synthesis methods and optical properties of the CQDs are discussed. Different types of CQDs-based sensors and biosensors and their working mechanisms are clarified.
关键词： Carbon quantum dots,Sensors,Electrochemiluminescence,Photoluminescnece,Chemiluminescence,Fluorescence resonance energy transfer
更新于2025-09-19 17:13:59
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Sulfur and nitrogen coa??doped graphene quantum dota??assisted chemiluminescence for sensitive detection of tryptophan and mercury (II)
摘要： A simple one-step thermal treatment to prepare strong fluorescent sulfur and nitrogen co-doped graphene quantum dots (SN-GQD) using citric acid and L-cysteine as precursors was developed. The ultra-weak chemiluminescence (CL) from the reaction of hydrogen peroxide (H2O2) and periodate (IO4?) was significantly enhanced by SN-GQD in acidic medium. The enhanced CL was induced by excited-state SN-GQD (SN-GQD*), which was produced from the transfer energy of (O2)2* and 1O2 to SN-GQD and recombination of oxidant-injected holes and electrons in SN-GQD. In the presence of tryptophan (Trp), the CL intensity of the SN-GQD–H2O2–KIO4 system was greatly diminished. This finding was used to design a novel method for determination of Trp in the linear range 0.6–20.0 μM, with a limit of detection (LOD) of 58.0 nM. Furthermore, Hg2+ was detectable in the range 0.1–9.0 μM with a LOD of 64.0 nM, based on its marked enhancement of the SN-GQD–H2O2–KIO4 CL system. The proposed method was successfully applied to detect Trp in milk and human plasma samples and Hg2+ in drinking water samples, with recoveries in the range 95.7–107.0%.
关键词： tryptophan,S,N co-doped graphene quantum dots,chemiluminescence,mercury (II)
更新于2025-09-16 10:30:52