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Comparison of Reliability in Diabetic Macular Edema Estimates between Two Image Analysis Algorithms
摘要： Purpose: To evaluate segmentation reliability in diabetic macular edema (DME) estimates between a CirrusTM HD-OCT image analysis algorithm and an Iowa reference algorithm, which are an automatic segmentation software. Methods: Thirty eyes from 23 patients diagnosed with DME were included and underwent spectral-domain optical coherence scans (CirrusTM HD-OCT). Central foveal thickness (CFT) and ganglion cell layer-inner plexiform layer segmentation data were compared with those produced by the CirrusTM HD-OCT segmentation algorithm and Iowa reference algorithm. Measurement agreement was assessed using intraclass correlation (ICC) and segmentation errors were confirmed by 2 ophthalmologists. Results: The mean CFT in the 1-mm central area determined by the manufacturer-supplied Cirrus software and Iowa reference algorithm was 512.07 ± 182.35 μm and 476.53 ± 32.36 μm, respectively (p < 0.05). The mean paired difference was 35.53 ± 92.46 μm (ICC, 0.929). Segmentation errors were demonstrated in eyes with a CFT less than 400 μm, specifically for 45% of scans obtained by the Cirrus algorithm and 9% from the Iowa algorithm; in eyes with a CFT equal to or higher than 400 μm, the error rates were 95% and 42%, respectively. Conclusions: CFT measurement in eyes with diabetic macular edema using the Cirrus algorithm and Iowa algorithm showed relatively high degrees of agreement and significant correlation. In eyes with a CFT equal to or higher than 400 μm, the Iowa algorithm showed higher reliability in retinal segmentation than the Cirrus algorithm.
关键词： Reliability,Segmentation algorithm,Diabetic macular edema,Optical coherence tomography,Central foveal thickness
更新于2025-09-10 09:29:36
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Clinical Correlation between Retinal Sensitivity and Foveal Thickness in Retinitis Pigmentosa Patients
摘要： Purpose: To investigate the relationship between retinal structure and retinal sensitivity comparing data obtained using spectral-domain optical coherence tomography (SD-OCT) and microperimetry in retinitis pigmentosa (RP) and healthy patients. Methods: A total of 49 patients (98 eyes) with RP were divided into 4 groups according to the OCT findings: group A, patients with no macular changes; group B, patients with cystoid macular edema (CME); group C, patients with vitreomacular traction (VMT); group D, patients with retinal thinning. As a control group, we enrolled 27 healthy subjects. All subjects underwent a complete ophthalmologic examination, including SD-OCT and microperimetry. For the statistical analysis, Pearson correlation test and linear regression analysis were used. A p value <0.05 was considered statistically significant. Results: We did not find any significant difference in best-corrected visual acuity (BCVA), foveal thickness, or retinal sensitivity between group A and the healthy subjects (p>0.05). In group B, linear regression of logMAR versus foveal thickness and retinal sensitivity versus foveal thickness gave r values of 0.931 and 0.786, respectively. In group C, r values were 0.786 and 0.842, respectively, while in group D they were 0.816 and 0.795. Conclusions: This article shows the first application of the new microperimeter MP3 in patients with RP, which has proven to be very sensitive in detecting functional abnormalities in all the patients. Future studies should investigate the relationships among photoreceptor cell loss, retinal sensitivity, and fixation in patients with RP.
关键词： MP3,Microperimetry,Retinitis pigmentosa,Optical coherence tomography,Retinal sensitivity,Foveal thickness
更新于2025-09-10 09:29:36