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Determination of BCM-7 based on an ultrasensitive aptasensor fabricated of gold nanoparticles and ZnS quantum dots
摘要： In this study, an ultrasensitive electrochemical aptasensor for the determination of the β-casomorphin 7 (BCM-7) as a promising biomarker of autism disorder is introduced. According to the proposed strategy, a glassy carbon electrode (GCE) was modi?ed by thiourea capped-ZnS QDs (ZnS-QDs) and gold nanoparticles (AuNPs) to further immobilization the amino-aptamer (NH2-Apt) on its surface. The NH2-Apt as a receptor of the BCM-7 was attached to the embedded surface via a formation of the Au–N bonds between the AuNPs and amino groups of the Apt. The evaluation of aptasensor by various electrochemical techniques exhibited successful sensing of the BCM-7 under two broad linear concentration ranges from 1 fM to 0.6 μM with a limit of detection (LOD) down to 350 aM. Also, the performance of the aptasensor in BCM-7 detection in real human urine samples was satisfactorily investigated. These ?ndings may facilitate distinguish of this challenging disorder and help human health.
关键词： Thiourea capped-ZnS QDs,β-casomorphin 7,Glassy carbon electrode,Gold nanoparticles,Aptasensor,Autism
更新于2025-09-23 15:21:01
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Semiconductor α-Fe <sub/>2</sub> O <sub/>3</sub> Hematite Fabricated Electrode for Sensitive Detection of Phenolic Pollutants
摘要： Hematite (α-Fe2O3) semiconductor is an abundant and non-toxic catalyst for different (photo)electrochemical reactions. In this work, a selective p-nitrophenol sensor was developed by fabricating a thin-layer of a glassy carbon electrode (GCE) with 5% nafion coating binders onto α-Fe2O3 thin film synthesized by a simple and inexpensive process. High sensitivity including long-term stability, and enhanced linear dynamic range, electrochemical performance towards p-nitrophenol were achieved by a reliable current-voltage method. A linear calibration curve was observed over a wide range of p-nitrophenol concentrations. Very low detection limit (0.6 ? 0.02 nM), good limit of quantification (2.0 nM) and high sensor sensitivity (K = 74.1 μA?cm(cid:0) 2) are calculated based on noise to signal ratio of ～ 3 N/S. Very importantly, the detection range covers over 7 orders of magnitude concentrations, from nM to mM. Figures of merits are comparable with best reported results whilst using a very simple device configuration. We show that hematite is an excellent material for the development of chemical sensors to detect hazardous compounds for environmental safety in a broad scale of concentrations.
关键词： Environmental safety,Sensitivity,p-Nitrophenol sensor,Hematite α-Fe2O3,Glassy carbon electrode
更新于2025-09-23 15:21:01
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Light enhanced electrochemistry and electrochemiluminescence of luminol at glassy carbon electrodes
摘要： We report in this work the enhancement effect of light irradiation on the electrochemistry and electrochemiluminescence (ECL) of luminol at the bare glassy carbon electrode (GCE). Light irradiation on the GCE surface induced the formation of hot electron-hole pairs. In alkaline solutions, hot holes can oxidize hydroxide anions to hydroxyl radicals that are capable of promoting the oxidation of luminol to generate larger current and stronger ECL. Moreover, the stability of current and ECL is also significantly improved upon light irradiation. This study provides a simple method to enhance the electrochemistry and ECL of luminol that have promise in improving the sensitivity of luminol-based chemical analysis and bioanalysis.
关键词： light irradiation,electrochemiluminescence,glassy carbon electrode,luminol,hot hole
更新于2025-09-10 09:29:36