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Imaging Glaucomatous Damage Across the Temporal Raphe
摘要： PURPOSE. To image and analyze anatomical differences at the temporal raphe between normal and glaucomatous eyes using adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography (OCT), and to relate these differences to visual ?eld measurements. METHODS. Nine glaucomatous eyes of 9 patients (age 54–78 years, mean deviation of visual ?eld [MD] (cid:2)5.03 to (cid:2)0.20 dB) and 10 normal eyes of 10 controls (age 54–81, MD (cid:2)1.13 to t1.39 dB) were enrolled. All the participants were imaged in a region that was centered approximately 98 temporal to the fovea. The size of imaging region was at least 108 vertically by 48 horizontally. The raphe gap, de?ned as the distance between the superior and inferior retinal nerve ?ber layer (RNFL) bundles, was measured. A bundle index was computed to quantify the relative re?ectivity and density of the nerve ?ber bundles. We also measured thickness of the ganglion cell complex (GCC) and RNFL. RESULTS. The raphe gap was larger in glaucomatous eyes than control eyes. Speci?cally, eight glaucomatous eyes with local averaged ?eld loss no worse than (cid:2)3.5 dB had larger raphe gaps than all control eyes. The bundle index, GCC thickness, and RNFL thickness were on average reduced in glaucomatous eyes, with the ?rst two showing statistically signi?cant differences between the two groups. CONCLUSIONS. Structural changes in the temporal raphe were observed and quanti?ed even when local functional loss was mild. These techniques open the possibility of using the raphe as a site for glaucoma research and clinical assessment.
关键词： visual ?eld,OCT,raphe,glaucoma,adaptive optics
更新于2025-09-04 15:30:14
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Retinal and Macular Ganglion Cell Count Estimated With Optical Coherence Tomography RTVUE-100 as a Candidate Biomarker for Glaucoma
摘要： To evaluate the ability of total and macular estimated retinal ganglion cell (RGC) counts to discriminate between healthy and glaucomatous eyes. To determine threshold markers of the estimated RGCs taking into account age dependence.
关键词： ganglion cells,optical coherence tomography,glaucoma
更新于2025-09-04 15:30:14
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Effectiveness of Glaucoma Diagnostic Parameters from Spectral Domain-Optical Coherence Tomography of Myopic Patients
摘要： 目的：目前频域光学相干成像（SD?OCT）可作为青光眼诊断的新工具。因此本文评价了SD?OCT所提供的青光眼诊断参数在不同屈光度近视患者中的诊断能力。 方法：横断面研究。共有248例受试者（248眼）入选。包括早期开角型青光眼组51，正常人组79例（±0.50D之内），低度近视组47例（?0.50 D to ?3.00 D（不包括）），中度近视组43例（?3.00 D to ?6.00 D（不包括）），高度近视组28例（≤?6.00 D）。所有受试者均行眼科常规检查及Humphrey 视野计、SD?OCT检查，将OCT检查所获得的视网膜神经纤维层(RNFL)和节细胞复合体（GCC））的相关参数进行统计学分析，分别绘制受试者操作曲线（ROC）并计算曲线下面积（AUC）。 结果：AUC结果如下：正常人、低度近视眼组的AUC最佳参数均为下方、颞下方RNFL厚度（AUC均﹥0.94），而中度近视、高度近视组的最佳参数均为颞下方参数（AUC分别为0.926，0.896），而中度近视组下方参数的AUC较?。?.864）排在所有RNFL参数的第15位。对文献中公认的诊断青光眼能力强的参数（下方、颞下方、颞上方）进行进一步分析，当灵敏度为85%时，这些参数在正视眼、低度近视眼组的特异度较高，均大于80%，而在中度近视、高度近视组特异度均较低，约在20%～60%。根据机器数据库所得绿色部分在高度近视组也较其他组少（P < 0.05）。 结论：SD?OCT的青光眼诊断参数在应用于中高度近视眼时的诊断能力较弱，特异度明显偏低，对中高度近视者进行青光眼的诊断时需综合分析。同时建议SD?OCT的正常人数据库应针对不同屈光度进行补充完善。
关键词： Glaucoma,Retina,Myopia,Nerve Fibers,Open Angle
更新于2025-09-04 15:30:14