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Portable infrared imaging for longitudinal limb volume monitoring in patients with lymphatic filariasis
摘要： Background The Global Programme to Eliminate Lymphatic Filariasis (LF) emphasizes hygiene, exercise, and other measures to reduce morbidity and disability related to LF. We recently reported that a portable, three-dimensional, infrared imaging system (3DIS) provides accurate limb volume measurements in patients with filarial lymphedema. To assess the practical utility of repeated 3DIS measurements for longitudinal lymphedema management, we examined intraday and day-to-day leg volume changes in adults with filarial lymphedema in southern Sri Lanka. Methodology and principal findings We assessed 41 participants with lower extremity lymphedema (stages 1–6) in their homes in the mornings (6:00–9:00 AM) and afternoons (2:00–6:00 PM) of three days within one calendar week. Two examiners performed replicate 3DIS volume measurements at each visit. Median coefficient of variation among replicate volume measurements was 1.7% (IQR 1.1% - 2.3%) for left legs and 2.2% (IQR 1.6% - 2.8%) for right legs. Median intraday volume increase was 3.0%. Range among daily volume measurements tended to be lower for afternoon measurements (median 2.25%, IQR 1.4%– 5.4%) than for morning measurements (median 3.0%, IQR 1.4% - 8.4%). Conclusions and significance Limb volume measurements by 3DIS are accurate and reproducible, and this technique is feasible for use in patients’ homes. We have developed practical suggestions for optimal outcomes with 3DIS. Duplicate measurements should be performed and repeat assessments should be done at approximately the same time of day to minimize bias. Duplicate measures that vary by more than 8% should prompt review of scanning technique with a repeat measurement. With proper training and attention to technique, 3DIS can be a valuable tool for healthcare workers who work with lymphedema patients.
关键词： Lymphatic Filariasis,limb volume monitoring,3D imaging,lymphedema management,infrared imaging
更新于2025-09-16 10:30:52
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Near-Infrared Imaging with Second-Window Indocyanine Green in Newly Diagnosed High-Grade Gliomas Predicts Gadolinium Enhancement on Postoperative Magnetic Resonance Imaging
摘要： Purpose: Intraoperative molecular imaging with tumor-targeting fluorophores offers real-time detection of neoplastic tissue. The second window indocyanine green (SWIG) technique relies on passive accumulation of indocyanine green (ICG), a near-infrared fluorophore, in neoplastic tissues. In this study, we explore the ability of SWIG to detect neoplastic tissue and to predict postoperative magnetic resonance imaging (MRI) findings intraoperatively. Procedures: Retrospective data were collected from 36 patients with primary high-grade gliomas (HGG) enrolled as part of a larger trial between October 2014 and October 2018. Patients received systemic ICG infusions at 2.5–5 mg/kg 24 h preoperatively. Near-infrared fluorescence was recorded throughout the case and from biopsy specimens. The presence/location of residual SWIG signal after resection was compared to the presence/location of residual gadolinium enhancement on postoperative MRI. The extent of resection was not changed based on near-infrared imaging. Results: All 36 lesions demonstrated strong near-infrared fluorescence (signal-to-background = 6.8 ± 2.2) and 100 % of tumors reaching the cortex were visualized before durotomy. In 78 biopsy specimens, near-infrared imaging demonstrated higher sensitivity and accuracy than white light for diagnosing neoplastic tissue intraoperatively. Furthermore, near-infrared imaging predicted gadolinium enhancement on postoperative MRI with 91 % accuracy, with visualization of residual enhancement as small as 0.3 cm3. Patients with no residual near-infrared signal after resection were significantly more likely to have complete resection on postoperative MRI (p value G 0.0001). Conclusions: Intraoperative imaging with SWIG demonstrates highly sensitive detection of HGG tissue in real time. Furthermore, post-resection near-infrared imaging correlates with postoperative MRI. Overall, our findings suggest that SWIG can provide surgeons with MRI-like results in real time, potentially increasing resection rates.
关键词： Intraoperative MRI,Postoperative MRI,Indocyanine green,Near-infrared imaging,High-grade gliomas
更新于2025-09-16 10:30:52
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European Microscopy Congress 2016: Proceedings || Improving 3d correlation in integrated correlated light and electron microscopy using confocal laser scanning microscopy
摘要： Integrated optoelectronics for fast and efficient light detection and imaging in the infrared and visible spectrum.
关键词： optoelectronics,visible spectrum,light detection,infrared,imaging
更新于2025-09-16 10:30:52
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Sharp pH-responsive mannose prodrug polypeptide nanoparticles encapsulating a photosensitizer for enhanced near infrared imaging-guided photodynamic therapy
摘要： Mannose has been reported as a novel drug to kill cancer cells. The prodrug of mannose will promote its targeted delivery and enrichment at the tumor site and cancer cells. Here, a pH-sensitive polypeptide copolymer with a tertiary amine group has been prepared and a mannose molecule was conjugated to the polymer through the formation of a Schiff base. At the same time, an iodinated boron dipyrromethene (BDPI) photosensitizer with high singlet oxygen generation efficacy and near infrared (NIR) fluorescence was encapsulated by the nanoparticles, which makes it a potential pH-sensitive NIR imaging-guided chemotherapy/PDT agent. In vitro and in vivo studies reveal that in a tumor acidic environment, the protonation of the tertiary amine group destroyed the nanostructure of the nanoparticles, resulting in increased BDPI release. Meanwhile, the bond cleavage of the Schiff base led to the release of conjugated mannose and synergistic inhibition of tumor cell growth with the PDT effect was realized. The combination of these two kinds of tumor suppression effects and photodynamic therapy made this pH-sensitive polypeptide delivery system show great potential for further cancer therapy.
关键词： polypeptide nanoparticles,mannose prodrug,pH-responsive,photodynamic therapy,photosensitizer,near infrared imaging
更新于2025-09-16 10:30:52
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Quantitative characterization of super-resolution infrared imaging based on time-varying focal plane coding
摘要： High resolution infrared image has been the goal of an infrared imaging system. In this paper, a super-resolution infrared imaging method using time-varying coded mask is proposed based on focal plane coding and compressed sensing theory. The basic idea of this method is to set a coded mask on the focal plane of the optical system, and the same scene could be sampled many times repeatedly by using time-varying control coding strategy, the super-resolution image is further reconstructed by sparse optimization algorithm. The results of simulation are quantitatively evaluated by introducing the Peak Signal-to-Noise Ratio (PSNR) and Modulation Transfer Function (MTF), which illustrate that the effect of compressed measurement coef?cient r and coded mask resolution m on the reconstructed image quality. Research results show that the proposed method will promote infrared imaging quality effectively, which will be helpful for the practical design of new type of high resolution infrared imaging systems.
关键词： compressed sensing,focal plane coding,modulation transfer function,super-resolution,Infrared imaging system
更新于2025-09-16 10:30:52
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Broadband lightweight flat lenses for long-wave infrared imaging
摘要： We experimentally demonstrate imaging in the long-wave infrared (LWIR) spectral band (8 μm to 12 μm) using a single polymer flat lens based upon multilevel diffractive optics. The device thickness is only 10 μm, and chromatic aberrations are corrected over the entire LWIR band with one surface. Due to the drastic reduction in device thickness, we are able to utilize polymers with absorption in the LWIR, allowing for inexpensive manufacturing via imprint lithography. The weight of our lens is less than 100 times those of comparable refractive lenses. We fabricated and characterized 2 different flat lenses. Even with about 25% absorption losses, experiments show that our flat polymer lenses obtain good imaging with field of view of 35? and angular resolution less than 0.013?. The flat lenses were characterized with 2 different commercial LWIR image sensors. Finally, we show that, by using lossless, higher-refractive-index materials like silicon, focusing efficiencies in excess of 70% can be achieved over the entire LWIR band. Our results firmly establish the potential for lightweight, ultrathin, broadband lenses for high-quality imaging in the LWIR band.
关键词： diffractive lenses,infrared imaging,chromatic aberrations
更新于2025-09-16 10:30:52
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Research on Application Technology of Wave Gate in Anti-jamming for Infrared Detection
摘要： The principle of wave gate was introduced. Wave gate is a kind of anti-jamming technique. When finding aim, system made a bit of section in a signal detecting cycle as wave gate, and disposed only signal in wave gate, so scope of signal disposed was reduced. Wave gate had been applied successfully to guided weapon. With development of infrared imaging technology, wave gate is developed. It can reduce greatly computation and enhance capability of anti-jamming for infrared imaging detection. The experiment proved that the method had good effect.
关键词： infrared imaging technology,infrared detection,wave gate,anti-jamming
更新于2025-09-11 14:15:04
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Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors
摘要： Surgical excision is the foundation of treatment for early-stage solid tumors in man and companion animals. Complete excision with appropriate margins of surrounding tumor-free tissue is crucial to survival. Intraoperative imaging allows real-time visualization of tumors, assessment of surgical margins, and, potentially, lymph nodes and satellite metastatic lesions, allowing surgeons to perform complete tumor resections while sparing surrounding vital anatomic structures. This Review will focus on the use of near-infrared imaging and optical coherence tomography for intraoperative tumor visualization.
关键词： optical coherence tomography,tumors,intraoperative visualization,surgical excision,near-infrared imaging
更新于2025-09-11 14:15:04
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Synthesis and characterization of 64Cu- and Cy5.5-labeled tetraiodothyroacetic acid derivatives for tumor angiogenesis imaging
摘要： It was previously reported that tetraiodothyroacetic acid (tetrac) inhibits angiogenesis by binding to the cell surface receptor for thyroid hormone on integrin αVβ3. Therefore, we synthesized and evaluated two 64Cu-labeled tetrac derivatives and a Cy5.5-labeled tetrac derivative for tumor angiogenesis imaging. Tetrac was structurally modified to conjugate with 1,4,7,10-tetraazacyclododecane-N,N′,N″,N″′-tetraacetic acid (DOTA) via its hydroxy or carboxylic acid end, and the resulting DOTA-conjugated tetrac derivatives were then labeled with 64Cu. Tetrac was also conjugated with Cy5.5 via its carboxylic acid end. All three tetrac derivatives (1–3) exhibited greater inhibitory activity than tetrac against endothelial cell tube formation. The U87MG cell binding of [64Cu]2 showed a time-dependent increase over 24 h and it was inhibited by 38% at 4 h in the presence of tetrac, indicating specificity of [64Cu]2 to the thyroid hormone receptor site on integrin αVβ3. Positron emission tomography (PET) images of U87MG tumor-bearing mice injected with [64Cu]1 and [64Cu]2 revealed that high radioactivity accumulated in the tumors, and that the tumor uptake and tumor-to-nontarget uptake ratio were higher in small tumors than in large tumors. In addition, the Cy5.5-labeled tetrac derivative (3) displayed a strong near-infrared (NIR) signal in the tumors. Taken together, these results suggest that these ligands hold promise as imaging agents for visualization of tumor angiogenesis.
关键词： Near-infrared imaging,Integrin αVβ3,Angiogenesis,Positron emission tomography,Tetraiodothyroacetic acid
更新于2025-09-11 14:15:04
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Effects of interfaces and current spreading on the thermal transport of micro-LEDs for kA-per-square-cm current injection levels
摘要： The three-dimensional thermal characteristics of micro-light-emitting diodes (mLEDs) on GaN and sapphire substrates were studied with forward-voltage methods, thermal transient measurements, and infrared imaging. The mLEDs on the GaN substrate showed an approximately 10 °C lower junction temperature and smaller amplitude of the K factors than those on the sapphire substrate under the current injection level of 4 kA cm?2. The thermal transient measurement showed that the spreading thermal resistances of the mesa, the GaN epilayer, and the interface of the GaN/substrate were reduced significantly for mLEDs on the GaN substrate because of the high-quality GaN crystal and the interfaces. The infrared thermal images showed lower total average junction temperatures and more uniform temperature distributions for the mLEDs on the GaN substrate, which were also simulated with APSYS software. The thermal transport mechanisms are discussed for the lateral and vertical directions in the mLEDs.
关键词： sapphire substrate,micro-light-emitting diodes,GaN substrate,junction temperature,thermal transport,infrared imaging,APSYS simulation
更新于2025-09-11 14:15:04