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N-arylated bisferrocene pyrazole for dual-mode detection of hydrogen peroxide: AIE-active fluorescent “turn on/off” and electrochemical non-enzymatic sensor
摘要： A series of new N?arylated bisferrocene pyrazole (D-π-A-π-D) chromophores have been synthesized by the Chan?Lam cross-coupling (1, 2) and Buchwald–Hartwig amination (3, 4) reactions. The compounds 1-4 were characterized with the aid of analytical and spectroscopic methods. The solvatochromism behaviour of compounds (1, 3) showed positive solvatochromism and later (2, 4) exhibited negative solvatochromism. The compounds 1-4 interestingly showcased high-enhanced fluorescent intensity in their aggregate state while in the solution state they exhibited low fluorescent intensity behaviour. The origin of enhanced emission in the aggregated state is due to a restriction of intramolecular rotation, especially in the ratio of mixture 40:60 (CH3CN/H2O). The aggregation-induced emission(AIE) properties were utilized to detect the H2O2 which show quick response in a linear range of 10-50 μM with a detection limit of 38.8 nM (1) and 15.9 nM (3). Furthermore, the electrochemical reduction of hydrogen peroxide in the same linear range as above showed and a limit of detection (3σ) of 14.4 mM (1) and 11.6 mM (3).
关键词： Dual-mode detection of H2O2,Electrochemical non?enzymatic sensor,AIE-active luminogens
更新于2025-11-14 15:29:11
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Prussian Blue Nanocubesa??SnO <sub/>2</sub> Quantum Dotsa??Reduced Graphene Oxide Ternary Nanocomposite: An Efficient Nona??noblea??metal Electrocatalyst for Nona??enzymatic Detection of H <sub/>2</sub> O <sub/>2</sub>
摘要： Developing non-noble-metal electrocatalyst for non-enzymatic H2O2 sensing is highly attractive. A facile, two-step approach has been utilized for the synthesis of PBNCs/SnO2 QDs/RGO ternary nanocomposite. TEM, SEM, XPS, and XRD techniques were used to the characterize the structural and morphological properties of synthesized ternary nanocomposite. The synthesized ternary nanocomposite has been examined as an electrode material for the electrochemical detection of H2O2 using the Amperometry technique. Under optimum conditions, PBNCs/SnO2 QDs/RGO ternary nanocomposite performed very well in the electrocatalytic reduction of H2O2 with a linear dynamic range from 25-225 μM (R2 = 0.996) with a low detection limit of 71 nM (S/N=3). Compared to the recent literature, PBNCs/SnO2QDs/RGO ternary nanocomposite based modified electrode exhibit a wider linear dynamic range with a low detection limit. Furthermore, PBNCs/SnO2 QDs/RGO ternary nanocomposite based modified electrode showed an excellent anti-interference ability against various common interfering agents. The practical applicability of ternary nanocomposite based modified electrode was further extended to determine the H2O2 in tap water with acceptable recovery. The present performance of PBNCs/SnO2 QDs/RGO ternary nanocomposite material towards H2O2 sensing might widen its application for developing a new type of non-noble metal-based non-enzymatic electrochemical biosensors.
关键词： Hydrogen peroxide,Graphene,Non-enzymatic sensor,SnO2 quantum dots,Non-noble-metal electrocatalyst,Prussian blue nanocubes
更新于2025-09-23 15:21:01
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Surface Engineering of Laser-Scribed Graphene Sensor Enables Non-Enzymatic Glucose Detection in Human Body Fluids
摘要： Contemporary devices for glucose monitoring predominantly rely on finger-pricked blood through an enzyme-catalyzed reaction. However, the enzymes are highly expensive, unstable and require complex procedures for integration with the sensing matrix, rendering strategic replacement by non-enzymatic sensors. Here, a non-enzymatic glucose sensor is developed based on surface engineering of laser scribed graphene (LSG) - an immerging 3D patterned graphene - that combines binder-free, highly porous, conducting graphitic carbon network. An easy and green method is developed to engineer LSG surface by conformal anchoring of copper oxide nanoparticles (CuO NPs) of optimized NP size for enhancing its catalytic efficacy. The device shows excellent non-enzymatic glucose sensing performance (0.4 V detection potential vs. printed Ag/AgCl reference electrode, ? 0.2 s response time, 0.1 μM detection limit, 1 μM-5 mM linearity and high selectivity). Noteworthy, the device exhibits high stability and reproducibility for glucose in human body fluids (whole blood, serum, sweat, and urine). In addition, conformal transfer of LSG to commercial scotch tape (LSGST) enables wearability of the device on curvilinear body parts, exemplified through miniaturized devices monitoring glucose in sweat directly. These findings pave a new path for a comprehensive personalized healthcare strategy by accurate non-enzymatic detection of glucose from human body fluids.
关键词： Laser-scribed graphene,Miniaturized device,Glucose,Scotch tape,Non-enzymatic sensor
更新于2025-09-12 10:27:22