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Near-Infrared fluorescence chemosensor based on isothiocyanate-aza-BODIPY for cyanide detection in ppb level: Applications in buffer media and living cell imaging
摘要： A near-infrared chemodosimeter based on an aza-BODIPY dye was designed and synthesized. The sensor contains isothiocyanate groups for cyanide ion sensing. The sensing function was illustrated via the fluorescence changes in near-infrared frequencies as well as chromogenic change which could be easily visualized with a detection limit of 19 ppb. The sensor provides high selectivity to CN? and discriminates other anions such as CH3COO?, HPO4 2?, HSO4 ?, NO3 ?, Cl?, F?, Br?, I?, ClO3 ?, CO3 2?, SO4 2?, and phenylalanine (Phe) in 50% PBS buffer/acetonitrile at physiological pH. The potential of the sensor for CN? detection in both aqueous buffer solutions and living cells imaging were demonstrated.
关键词： selectivity,cyanide,sensors,aza-BODIPY dyes,near-infrared fluorescence
更新于2025-09-23 15:23:52
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A promising family of fluorescent water-soluble aza-BODIPY dyes for in vivo molecular imaging
摘要： A new family of water-soluble and bioconjugatable aza-BODIPY fluorophores was designed and synthesized using a boron-functionalization strategy. These dissymmetric bis-ammonium aza-BODIPY dyes present optimal properties for a fluorescent probe, i.e. they are highly water-soluble, very stable in physiological medium, they do not aggregate in PBS, possess high quantum yield and finally they can be easily bioconjugated to antibodies. Preliminary in vitro and in vivo studies were performed for one of these fluorophores to image PD-L1 (Programmed Death-Ligand 1), highlighting the high potential of these new probes for future in vivo optical imaging studies.
关键词： molecular Imaging,Fluorescent probes,boron functionalization,aza-BODIPY,Water-soluble fluorophores
更新于2025-09-23 15:23:52
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Rational design of pyrrolopyrrole-aza-BODIPY-based acceptora??donora??acceptor triads for organic photovoltaics application
摘要： Acceptor-donor-acceptor triads consisting of diketopyrrolopyrrole (DPP) or pyrrolopyrrole aza-BODIPY (PPAB) or both as acceptors and cyclopentadithiophene as a donor were rationally designed for near infrared (NIR) photovoltaics application. Among them, the PPAB-based triad exhibited the highest power conversion efficiency of 3.88% owing to the panchromatic absorption in the UV/vis/NIR regions.
关键词： pyrrolopyrrole-aza-BODIPY,organic photovoltaics,acceptor-donor-acceptor triads,near infrared photovoltaics
更新于2025-09-23 15:19:57
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Highly Stable and Multifunctional Aza-BODIPY-Based Phototherapeutic Agent for Anticancer Treatment
摘要： Phototherapy, as an important class of noninvasive tumor treatment methods, has attracted extensive research interest. Although a large amount of the near-infrared (NIR) phototherapeutic agents have been reported, the low efficiency, complicated structures, tedious synthetic procedures, and poor photostability limit their practical applications. To solve these problems, herein, a donor?acceptor?donor (D?A?D) type organic phototherapeutic agent (B-3) based on NIR aza-boron-dipyrromethene (aza-BODIPY) dye has been constructed, which shows the enhanced photothermal conversion efficiency and high singlet oxygen generation ability by simultaneously utilizing intramolecular photoinduced electron transfer (IPET) mechanism and heavy atom effects. After facile encapsulation of B-3 by amphiphilic DSPE?mPEG5000 and F108, the formed nanoparticles (B-3 NPs) exhibit the excellent photothermal stabilities and reactive oxygen and nitrogen species (RONS) resistance compared with indocyanine green (ICG) proved for theranostic application. Noteworthily, the B-3 NPs can remain outstanding photothermal conversion efficiency (η = 43.0%) as well as continuous singlet oxygen generation ability upon irradiation under a single-wavelength light. Importantly, B-3 NPs can effectively eliminate the tumors with no recurrence via synergistic photothermal/photodynamic therapy under mild condition. The exploration elaborates the photothermal conversion mechanism of small organic compounds and provides a guidance to develop excellent multifunctional NIR phototherapeutic agents for the promising clinical applications.
关键词： heavy atom effects,intramolecular photoinduced electron transfer,donor?acceptor?donor type,NIR phototherapeutic agents,aza-BODIPY
更新于2025-09-10 09:29:36