- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
A Phosphonate Substituted Ruthenium(II) Bipyridyl Derivative as Photoelectrochemical Probe for Sensitive and Selective Detection of Mercury(II) in Biofluids
摘要： A ruthenium(II) bipyridyl derivative photoelectrochemical probe, Ru-1, is synthesized and coupled with TiO2 nanoparticles (Ru-1/TiO2) for the specific recognition and highly sensitive PEC detection of Hg2+ in a series of biofluids. The probe is designed with a chromophore, a thiocyanate recognition unit, a π-conjugated photoelectron transfer pathway, and a phosphonate anchor. TiO2 nanoparticles with strong affinity to phosphonate and suitable conduction band energy are used as intermediate layers to increase the Ru-1 adsorption amount and amplify the photocurrent response. Under irradiation, the Ru-1/TiO2/FTO with strong visible light harvesting capacity, aqueous stability and efficient photoelectron transfer, shows a high and stable photocurrent response. In the presence of Hg2+, however, the specific Hg2+ and NCS coordination changes the photophysical properties of Ru-1, imposing the probe with a wider band gap, a weaker absorbance, and a poorer photoelectron and hole separation efficiency, thus resulting in a significant photocurrent decrease. Based on the Hg2+ induced photocurrent change, the Ru-1/TiO2/FTO shows good selectivity and high sensitivity towards the PEC detection of Hg2+, with wide linear ranges from 10-12 to 10-7 and 10-7 to 10-3 g/mL, and a low limit of detection of 0.63 pg/mL. The PEC probe is recyclable and accurate for selective detection of Hg2+ in urine, serum and cell extracts. The whole analysis can be completed within 15 minutes. These good analytical performances indicate the PEC method might have great potential for the onsite detection of small molecules in bio-systems.
关键词： Hg2+ detection,photoelectrochemical probe,TiO2 nanoparticles,ruthenium(II) bipyridyl derivative,biofluids
更新于2025-09-23 15:21:21
-
Rapid and sensitive surface-enhanced resonance Raman spectroscopy detection for norepinephrine in biofluids
摘要： Norepinephrine (NE) is a kind of catecholamine neurotransmitter that participates significant function in living organism. Rapid and sensitive detection target in complex system is crucial in analytical science. A facile ferric citrate (CA‐Fe (III)) sensor was designed successfully for sensitive detection of NE by surface‐enhanced resonance Raman spectroscopy (SERRS) method. This CA‐Fe (III) sensor was prepared by modifying Fe (III) on the surface of uniform Au nanoparticles (NPs) wrapped with citrate (CA) stabilizer. The implementation of NE selective detection is attributed to significant enhancement provided by Au NPs and additional enhancement provided by ligand‐to‐metal charge transfer between chromophore and analyte. In addition, a universal CH3OH, HCl, and petroleum ether added in sequence pretreatment method was developed and applied to purify and enrich the target in practical biological sample, realizing selective detection of NE in biofluids. This novel sensor combined with SERRS and pretreatment strategy not only amplifies the Raman signal of NE but also paves the way for pretreating sample in complex system.
关键词： norepinephrine,pretreatment method,ferric citrate sensor,surface‐enhanced resonance Raman spectroscopy,biofluids
更新于2025-09-23 15:21:01