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- 摘要
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- 实验方案
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[IEEE 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS) - Cleveland, OH, USA (2018.10.17-2018.10.19)] 2018 IEEE Biomedical Circuits and Systems Conference (BioCAS) - Battery-Free. Sticker-Like, Device for Health Monitoring, Operated by Optical Power Transfer
摘要： This work presents the concept of a battery-free, sticker-like, device for a non-invasive health-monitoring sensor. The device consists of two functional blocks: an optical power-transfer block and an amperometric measurement block. The former accumulates power from a series-connected photovoltaic cell in a capacitor and intermittently supplies the power to the amperometric measurement circuit. This circuit is driven by powering pulses and displays the amperometric current as the durations of the light pulses from a light-emitting diode. The function of the circuit was successfully demonstrated through simulations, in which the equivalent circuit of an electrochemical glucose sensor was used as an example. The simulation results showed that the proposed device would work as expected for a variety of glucose concentrations at an oxidation voltage of 0.8 V.
关键词： optical power transfer,personalized medicine,battery-free,non-invasive,glucose monitoring,electrochemical
更新于2025-09-23 15:22:29
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Overcoming Individual Discrepancies, a Learning Model for Non-Invasive Blood Glucose Measurement
摘要： Non-invasive Glucose Measurement (NGM) technology makes great sense for the blood glucose management of patients with hyperglycemia or hypoglycemia. Individual Discrepancies (IDs), e.g., skin thickness and color, not only block the development of NGM, but also become the reason why NGM cannot be widely used. To solve this problem, our solution is designing an individual customized NGM model that can measure these discrepancies through multi-wavelength and tune parameters for glucose estimating. In this paper, an NGM prototype is designed, and a learning model for glucose estimating with automatically parameters tuning based on Independent Component Analysis (ICA) and Random Forest (RF) is presented. The clinic trial proves that the correlation coefficient between estimation and reference Blood Glucose Concentration (BGC) can reach 0.5 after merely 10 times of learning, and rise to 0.8 after about 60 times of learning.
关键词： Independent Component Analysis (ICA),random forest,non-invasive,blood glucose,diabetes
更新于2025-09-23 15:22:29
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Photodeposition of palladium nanoparticles on a porous gallium nitride electrode for nonenzymatic electrochemical sensing of glucose
摘要： A nonenzymatic electrochemical glucose sensor is described that was obtained by in situ photodeposition of high-density and uniformly distributed palladium nanoparticles (PdNPs) on a porous gallium nitride (PGaN) electrode. Cyclic voltammetric and chronoamperometric techniques were used to characterize the performance of the modified electrode toward glucose. In 0.1 M NaOH solution, it has two linear detection ranges, one from 1 μM to 1 mM, and another from 1 to 10 mM, and the detection limit is 1 μM. The electrode is repeatable, highly sensitive, fast and long-term stable. It was applied to the quantitation of serum glucose where it displayed accurate current responses.
关键词： Electrochemical sensing,Gallium nitride,Photodeposition,Glucose detection,Palladium nanoparticles,Porous materials
更新于2025-09-23 15:22:29
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Template Synthesis, Spectral, Thermal and Glucose Sensing of Pr3+ Complexes of Metformin Schiff-Bases
摘要： Schiff-bases of metformin with each of salicylaldehyde (HL1); 2,3-dihydroxybenzaldehyde (H2L2); 2,4-dihydroxybenzaldehyde (H2L3); 2,5-dihydroxybenzaldehyde (H2L4); 3,4-dihydroxybenzaldehyde (H2L5) and 2-hydroxynaphthaldehyde (HL6) and their complexes with Pr(III) were synthesized by template reaction. The complexes were characterized through elemental analysis, conductivity and magnetic moment measurements, IR, UV-Vis., fluorescence, GC-MS and XRD spectroscopy. The complexes exhibit a series of characteristic emission bands for Pr3+ ion in the 481-472 and 590-580 nm range with a 318-332 nm excitation source. The complexes have eight coordinated structure with the formulae [PrL1-4,6(NO3)2(H2O)3].nH2O where n = 1, 1?, 3, 4, 4 and [PrL5(NO3)(H2O)5].2H2O. The suggested stereochemistry was confirmed using TGA, DTG and DTA analysis and a mechanism for thermal decomposition was proposed. Coates-Redfern equation was used to calculate kinetic and thermodynamic parameters of the main decomposition step. The utility of the complexes towards the detection of glucose at physiologically relevant pH in phosphate buffer using UV-Vis and fluorescence spectroscopy as well as viscosity measurements are tried where the association constants were calculated.
关键词： Pr(III) complexes,Spectral and thermal properties,Glucose sensing,Metformin Schiff-bases
更新于2025-09-23 15:22:29
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A photoelectrochemical glucose and lactose biosensor consisting of gold nanoparticles, MnO2 and g-C3N4 decorated TiO2
摘要： In this study, an innovative light-sensitive hybrid material was used for photoelectrochemical (PEC) biosensor fabrication. Herein, gold nanoparticles modified mesoporous TiO2 was coated on an indium tin oxide substrate, after a layer of MnO2/g-C3N4 was introduced to develop a PEC biosensor that yielded a favorable electronic interface for photo-excited electron injection. Glucose oxidase and β-galactosidase were co-immobilized on the photoanode surface via silane/glutaraldehyde linkage chemistry for glucose and lactose determination. Au NPs, g-C3N4, and MnO2 were utilized to modify quintessential semiconductor TiO2 owing to their narrow band gaps, appropriate position of the valence and conduction bands, and high visible light absorption. The p–n heterojunction formation at the interface of MnO2 and g-C3N4/TiO2 was presumed, and the heterojunction facilitates the charge transport and inhibit the recombination of excited electrons. Direct electron transfer led to the hole scavenging by FADH2, which reinforced the photocurrent. The linear measurement ranges were calculated in the range of 0.004-1.75 mM, with a sensitivity of 1.54 μAmM?1cm?2 for glucose at 0 V, and 0.008-2.50 mM, with a sensitivity of 1.66 μAmM?1cm?2 for lactose at -0.4 V. To the best of our knowledge, we report the first PEC lactose biosensor, and this study opens the door to PEC multianalyte detection.
关键词： β-galactosidase,g-C3N4,Self-powered biosensor,Glucose oxidase,Gold nanoparticles
更新于2025-09-23 15:21:21
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Pseudo-Continuous Flow FTIR System for Glucose, Fructose and Sucrose Identification in Mid-IR Range
摘要： In this paper, we present a new FTIR-based micro?uidic system for Glucose, Fructose and Sucrose detection. The proposed micro?uidic system is based on a pseudo-continuous ?ow coupled to a microscope-FTIR instrument. The detection and characterization of sugar samples were performed by recording their absorption spectrum in the wavelength range 700–1000 cm?1 of the Mid-IR region. The proposed pseudo-continuous ?ow system is designed to improve the uniformity of the sample distribution in the analyzed area versus conventional systems. The obtained results for different sugars concentrations, show a very low measurement error of 4.35% in the absorption peak intensity, which is ten times lower than the error obtained using the conventional measurements.
关键词： mid-IR absorption spectroscopy,absorption spectrum,FTIR spectroscopy,microscopy-FTIR spectrometer,sugars detection and quanti?cation,Glucose,Fructose,Sucrose,pseudo-continuous ?ow
更新于2025-09-23 15:21:21
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Highly Sensitive Room-Temperature Sensor Based on Nanostructured K2W7O22 for Application in the Non-Invasive Diagnosis of Diabetes
摘要： Diabetes is one of the most rapidly-growing chronic diseases in the world. Acetone, a volatile organic compound in exhaled breath, shows a positive correlation with blood glucose and has proven to be a biomarker for type-1 diabetes. Measuring the level of acetone in exhaled breath can provide a non-invasive, low risk of infection, low cost, and convenient way to monitor the health condition of diabetics. There has been continuous demand for the improvement of this non-invasive, sensitive sensor system to provide a fast and real-time electronic readout of blood glucose levels. A novel nanostructured K2W7O22 has been recently used to test acetone with concentration from 0 parts-per-million (ppm) to 50 ppm at room temperature. The results revealed that a K2W7O22 sensor shows a sensitive response to acetone, but the detection limit is not ideal due to the limitations of the detection system of the device. In this paper, we report a K2W7O22 sensor with an improved sensitivity and detection limit by using an optimized circuit to minimize the electronic noise and increase the signal to noise ratio for the purpose of weak signal detection while the concentration of acetone is very low.
关键词： non-invasive,biomarker,ferroelectric property,blood glucose,volatile organic compound,acetone,nanostructured K2W7O22,diabetes
更新于2025-09-23 15:21:21
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Méga Guide STAGES IFSI || TEP scanner (ou PETscan)
摘要： Examen associant un scanner corps entier à une scintigraphie au glucose marqué par le fluor 18 (radio-isotope 18 FDG). Ainsi un hypermétabolisme (appelé ainsi car captant le glucose) repéré par la scintigraphie va pouvoir être anatomiquement précisé sur les coupes de scanner acquises simultanément.
关键词： fluor 18,TEP scanner,PETscan,glucose marqué,scintigraphie,hypermétabolisme
更新于2025-09-23 15:21:21
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Highly sensitive and selective sensor probe using glucose oxidase/gold nanoparticles/graphene oxide functionalized tapered optical fiber structure for detection of glucose
摘要： A tapered optical fiber structure based glucose sensor using graphene oxide (GO) and gold nanoparticles (AuNPs) is presented in this study. The waist diameter and length of the taper region are 25 μm and 6 mm, respectively. The taper region was created to expose the evanescent waves to the cladding boundaries and to get interact with the external medium. Further, the cladding of tapered region is covered with GO and AuNPs to increase the biocompatibility of sensor and to initiate the phenomenon of localized surface plasmon resonance (LSPR), respectively. The synthesized GO and AuNPs show the good absorbance properties at the peak absorbance wavelengths of 230 nm and 519 nm, respectively. The characterization of synthesized nanomaterials was done by using UV–vis spectrophotometer and TEM. The characterization of nanomaterial coated fiber probe was done by using SEM and SEM-EDS. The specificity of developed sensor probe is enhanced by immobilizing them with the glucose oxidase enzyme, that oxidized only in the presence of glucose solution. The attained results show that the developed sensor model is highly sensitive for the detection of glucose concentrations in human bodies with a sensitivity of 1.06 nm/mM in the linear range of 0 mM–11 mM with the autocorrelation accuracy of 0.9386.
关键词： Localized surface plasmon resonance,Glucose oxidase,Tapered optical fiber,Gold nanoparticles,Glucose,Graphene oxide
更新于2025-09-23 15:21:01
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Photoelectrochemical-assisted batch injection analysis (PEC-BIA) of glucose exploiting visible LED light as an excitation source
摘要： This work describes the development of a novel method for glucose determination exploiting a photoelectrochemical-assisted batch injection analysis cell designed and constructed with the aid of 3D printer technology. The PEC-BIA cell was coupled to a LED lamp in order to control the incidence of light on the Cu2O/Ni(OH)2/FTO photoelectroactive platform. The electrochemical characteristics of Cu2O/Ni(OH)2/FTO photoelectroactive platform were evaluated by cyclic voltammetry, amperometry, and electrochemical impedance spectroscopy. The PEC-BIA cell presented linear response range, limit of detection based on a signal-to-noise ratio of three, and sensitivity of 1 – 1000 μmol L-1, 0.76 μmol L-1 and 0.578 μA L μmol-1, respectively. The PEC-BIA method presented a mean value of the recovery values of 97.0 % to 102.0 % when it was applied to glucose determination in artificial blood plasma samples which indicates the promising performance of the proposed system to determine glucose.
关键词： Photoelectrochemistry,Visible LED light,Glucose,Batch injection analysis,3D-Printing,Cu2O/Ni(OH)2
更新于2025-09-23 15:21:01