- 标题
- 摘要
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- 实验方案
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Dual-functional supramolecular nanohybrids of quantum dot/biopolymer/chemotherapeutic drug for bioimaging and killing brain cancer cells in vitro
摘要： Glioblastoma (GBM) is the utmost aggressive and lethal primary brain cancer, which has a poor prognosis and remains virtually incurable. Nanomedicine with emerging disruptive nanotechnology alternatives, including designed supramolecular nanohybrids has excellent potential as multimodal tools against cancer by combining nanomaterials, biomacromolecules, and drugs. Thus, we developed and constructed for the first time quantum dot-biopolymer-drug nanohybrids based on host-guest chemistry for simultaneous bioimaging, targeting, and anti-cancer drug delivery against GBM cells in vitro. ZnS fluorescent quantum dots (ZnS-QDs) were produced using chemically modified polysaccharide, carboxymethylcellulose (CMC), as water-soluble capping ligand and biofunctional layer via a facile one-step eco-friendly aqueous colloidal process at room temperature and physiological pH. These hybrid inorganic-organic nanocolloids (ZnS@CMC) were electrostatically conjugated with doxorubicin (DOX) anti-cancer drug forming innovative supramolecular complexes (ZnS@CMC-DOX) for amalgamating bioimaging and killing cancer cells. These nanoconjugates were characterized regarding their optical and physicochemical properties combined with morphological and structural features. The cytocompatibility was evaluated by MTT assay using healthy and GBM cells. The results showed that ultra-small ZnS-QDs were expertly produced uniform nanocolloids (average size = 3.6 nm). They demonstrated photoluminescence emission within the visible range of spectra. The cell viability results in vitro showed no cytotoxicity of ZnS@CMC nanohybrids towards both cell types. In summary, the novelty of this research relies on using a nanotheranostic strategy for developing ZnS@CMC-DOX nanohybrids with supramolecular vesicle-like structures. They behaved simultaneously as active fluorescent nanoprobes and nanocarriers with modulated drug release for bioimaging and killing malignant glioma cells proving the high potential for applications in cancer nanomedicine.
关键词： Nanocarriers,Cancer nanotheranostic,Nanocolloids,Nanoconjugates,Fluorescent nanoparticles,Nanomedicine,Nanohybrids,Nanoparticles
更新于2025-09-12 10:27:22
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5 nm NiCoP nanoparticles coupled with g-C3N4 as high-performance photocatalyst for hydrogen evolution; 负载5 nm磷化钴镍纳米颗粒的石墨相氮化碳高效光催化产氢催化剂;
摘要： Graphitic carbon nitride (g-C3N4) coupled with NiCoP nanoparticles with sizes around 5 nm have been fabricated via a controllable alcohothermal process. NiCoP is an excellent electron conductor and cocatalyst in photocatalytic reactions. The coupling between tiny NiCoP nanoparticles and g-C3N4 through in-situ fabrication strategy could be a promising way to eliminate the light screening effect, hinder the recombination of photo-induced charge carriers, and improve the charge transfer. The NiCoP/g-C3N4 nanohybrids exhibit an excellent photocatalytic activity in the hydrogen generation, with a significantly improved performance compared with original g-C3N4, CoP/g-C3N4 and Ni2P/g-C3N4, respectively. This study paves a new way to design transition metal phosphides-based photocatalysts for hydrogen production.
关键词： nanohybrids,photocatalytic hydrogen generation,carbon nitride,transition metal phosphides
更新于2025-09-12 10:27:22
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Hybrid Nanostructures for Cancer Theranostics || Hybrid Nanostructures for In Vivo Imaging
摘要： Nanohybrids with well-defined optical properties and integrated functionalities are considered to be the most advanced next-generation blend of therapeutics and diagnostics: a simultaneous “theranostics”. Targeted delivery, real-time monitoring of administration, distribution, biotransformation, and elimination from the body are some of the beneficial attributes which have enabled it to get wide attention and acceptability. A spectrum of new-generation hybrid nanosystems for future biomedical applications has been fabricated, and has a variety of applications towards in vivo optical imaging, ultrasound (US) imaging, computed tomography (CT) of X-rays, magnetic resonance imaging (MRI), and positron emission tomography (PET). Multifunctional nanoparticles containing multiple contrast agents not only allow multimodal imaging but also improve the resolution of each of these imaging modalities. This chapter provides one of the most comprehensive detailed reports on the development of nanohybrids for cancer imaging to date.
关键词： Cancer imaging,Multimodal imaging,Theranostics,Contrast agents,Nanohybrids
更新于2025-09-10 09:29:36
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A facile synthesis of graphene nanoribbon-quantum dot hybrids and their application for composite electrolyte membrane in direct methanol fuel cells
摘要： In this work, we report the concept of synthesizing graphene nanoribbon-graphene quantum dot (GNR-GQD) hybrids with even grafting of GQD on GNR sheet in a facile single step process under ultrasonication in chlorosulfonic acid. Further, diazotization route is followed for the preparation of 4-benzenediazonium sulfonate precursor to sulfonate both GNR and GQD to form sulfonated graphene nanoribbons-sulfonated graphene quantum dots (sGNR-sGQD) nanohybrids. Synergistic and structure dependent effect of nanohybrids is seen via its dispersion in sulfonated poly(ether ether ketone) (sPEEK) to form nanocomposite membrane. sPEEK/sGNR-sGQD (1.5 wt. %) nanocomposite membrane shows remarkable direct methanol fuel cell (DMFC) performance compared to pristine sPEEK and Nafion 117 with 40 % increment in peak power density along with higher durability up to 100 h due to better physicochemical properties like water uptake, ion exchange capacity, proton conductivity, and reduced methanol crossover to suggest its potential which includes diverse membrane applications.
关键词： Graphene nanoribbon-graphene quantum dot hybrids,Nanohybrids,Nanocomposite membrane,Sulfonated poly(ether ether ketone),Direct methanol fuel cell
更新于2025-09-10 09:29:36
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Enhancement of Luminescence Intensity in Dy3+ Ions Doped YVO4 Nanomaterials by Ba2+ Ion Codoping and YVO4:2Dy/Fe3O4 Nanohybrid for Hyperthermia Application
摘要： The enhancement of the luminescence intensity of the Dy3+ by Ba2+ ions (at different concentrations) codoping into YVO4:2Dy nanoparticles at different annealing temperature of as-prepared, at 500 and 900°C were studied. The XRD study shows the strains are induced when dopant and codopant are incorporated into host matrix. XRD patterns of nanohybrids show the existence of two phases corresponding to YVO4:2Dy and Fe3O4 nanoparticles. TEM image of YVO4:2Dy nanoparticles were spherical shape whereas for YVO4:2Dy/Fe3O4 nanohybrids, the spherical particles are forming chain like structure due to the PEG molecule which binds both YVO4:2Dy and Fe3O4 during nanohybrids formation. Increase in absorption coefficient and decrease in lattice strain values are the major reasons for the enhancement of emission intensity in photoluminescent (PL). Lifetime studies also shows correlation between the calculated energy transfer and diffusion for indirect excitation which is also studied here. High quantum efficiency up to 45% can be achieved. YVO4:2Dy/Fe3O4 nanohybrids is found to achieve hyperthermia temperature 42°C in short time. This nanohybrids shows luminescence in the region of biological window indicating nanohybrids can be used as bioimaging probe. It also shows high viability up to 94% in HeLa cancer cells.
关键词： Vanadate nanoparticles,HeLa cell,Nanohybrids,Enhancement of luminescence,Hyperthermia
更新于2025-09-09 09:28:46