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An opsin 5–dopamine pathway mediates light-dependent vascular development in the eye
摘要： During mouse postnatal eye development, the embryonic hyaloid vascular network regresses from the vitreous as an adaption for high-acuity vision. This process occurs with precisely controlled timing. Here, we show that opsin 5 (OPN5; also known as neuropsin)-dependent retinal light responses regulate vascular development in the postnatal eye. In Opn5-null mice, hyaloid vessels regress precociously. We demonstrate that 380-nm light stimulation via OPN5 and VGAT (the vesicular GABA/glycine transporter) in retinal ganglion cells enhances the activity of inner retinal DAT (also known as SLC6A3; a dopamine reuptake transporter) and thus suppresses vitreal dopamine. In turn, dopamine acts directly on hyaloid vascular endothelial cells to suppress the activity of vascular endothelial growth factor receptor 2 (VEGFR2) and promote hyaloid vessel regression. With OPN5 loss of function, the vitreous dopamine level is elevated and results in premature hyaloid regression. These investigations identify violet light as a developmental timing cue that, via an OPN5–dopamine pathway, regulates optic axis clearance in preparation for visual function.
关键词： Hyaloid regression,Vascular development,Dopamine,VEGFR2,Light-dependent,Eye,Opsin 5,Retinal ganglion cells
更新于2025-11-21 11:20:42
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Self-template construction of honeycomb-like mesoporous YPO4:Ln3+ (Ln?=?Eu, Tb) phosphors with tuneable luminescent properties
摘要： Rare earth (RE)-based phosphors with mesoporous structure that can improve the absorption and utilization of light have attracted much attention recently. Herein, we develop a novel and facile self-template strategy to synthesize honeycomb-like mesoporous YPO4:Ln3+ (Ln = Eu, Tb) phosphors using Y4O(OH)9NO3: Ln3+ as the precursor through a simple H3PO4 etching process. The maximum specific surface area of the mesoporous YPO4:Ln3+ phosphors can reach 406 m2 g?1. The influence of mesoporous structure, crystallinity, and the concentration of rare earth ions on the photoluminescence performance of mesoporous YPO4:Ln3+ phosphors was investigated. The results of fluorescence measurements indicate the mesoporous YPO4:Ln3+ phosphors exhibit better photoluminescence performance after calcination at 900 °C due to the large surface area and high crystallinity. The optimum doped concentrations of Eu3+ and Tb3+ ions are 0.12 and 0.08, respectively, and the concentration quenching occurs among nearest-neighbor ions. This work provide a new sight on preparation of phosphors for white light-emitting diodes lamps.
关键词： Mesostructure,Ultrahigh specific surface area,Temperature dependent luminescence,Self-template strategy
更新于2025-11-14 17:15:25
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Solvent-Dependent Sensitization of Ytterbium and Neodymium via an Intramolecular Excimer
摘要： We report the synthesis of a di(1-pyrenyl)-phosphoryl acetophenone ligand containing two pyrenyl moieties linked by a single phosphorus atom. The ligand exhibits solvent-dependent emission: in nonpolar solvents, typical monomeric pyrene emission is observed, whereas in polar solvents, an additional broad and structureless emission appears. The emission in polar solvents is concentration independent and is attributed to the emission of an intramolecular excimer. The coordination of the di(1-pyrenyl)phosphoryl acetophenone ligand as well as the corresponding deprotonated anionic di(1-pyrenyl)phosphoryl acetophenonate ligand was studied with the near-infrared emitting lanthanides, neodymium and ytterbium. Solvent-dependent sensitization of both lanthanides was observed and correlates with the presence of the excimer emission. Sensitization of ytterbium is more efficient than neodymium, and the overall quantum yields were found to be 12.8 and 1.9% for ytterbium and neodymium, respectively.
关键词： solvent-dependent emission,quantum yields,ytterbium,neodymium,intramolecular excimer,lanthanides
更新于2025-11-14 15:24:45
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Barrier height modification in Au/Ti/n-GaAs devices with a $$\hbox {HfO}_{2}$$HfO2 interfacial layer formed by atomic layer deposition
摘要： X-ray photoelectron spectroscopy has been carried out to characterize the surface of the hafnia (HfO2) thin films grown on n-GaAs wafer by atomic layer deposition, and the surface morphology of the HfO2 layer on GaAs has been analysed using atomic force microscopy. The barrier height (BH) values of 1.03 and 0.93 eV (300 K) for the Au/Ti/HfO2/n-GaAs structures with 3- and 5-nm HfO2 interfacial layers, respectively, have been obtained from the I–V characteristics of the devices, which are higher than the value of 0.77 eV (300 K) for the Au/Ti/n-GaAs diode fabricated by us. Therefore, it can be said that the HfO2 thin layer at the metal/GaAs interface can also be used for BH modification as a gate insulator in GaAs metal-oxide semiconductor (MOS) capacitors and MOS field-effect transistors. The ideality factor values have been calculated as 1.028 and 2.72 eV at 400 and 60 K; and as 1.04 and 2.58 eV at 400 and 60 K for the metal–insulating layer–semiconductor (MIS) devices with 3- and 5-nm interfacial layers, respectively. The bias-dependent BH values have been calculated for the devices by both Norde’s method and Gaussian distribution (GD) of BHs at each sample temperature. At 320 K, the (cid:2)b(V ) value at 0.70 V for a 3-nm MIS diode is about 1.08 eV from the (cid:2)b(V ) vs. V curve determined by the GD, and about 0.99 eV at 0.58 V for a 5-nm MIS diode. It has been seen that these bias-dependent BH values are in close agreement with those obtained by Norde’s method for the same bias voltage values.
关键词： metal–insulating layer–semiconductor (MIS) device,Barrier height modification and inhomogeneous,bias-dependent barrier height,temperature-dependent MIS diode parameters,atomic layer deposition (ALD)
更新于2025-09-23 15:23:52
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The current-voltage characteristics of the ferroelectric p-YMnO3 thin film/bulk p-Si heterojunction over a broad measurement temperature range
摘要： The reverse and forward bias I-V characteristics of the Al/p-YMO/p-Si/Al heterojunction were measured at room temperature (RT) and over temperature range, from 50 to 320 K, and the I-V curves showed Schottky diode-like characteristics. The ideality factor and barrier height values were calculated as 0.81 and 2.62 from the forward bias I-V curve at room temperature (300 K), respectively. The YMO powder was prepared via solid state reaction technique. YMO thin films were grown on front surface of p-Si substrate by radio frequency (rf) magnetron sputtering using a polycrystalline YMO single target. The YMO thin film thickness on Si substrate was measured as ~70 nm via Dektak XT surface profilometer. The XRD, SEM, UV-Vis and XPS measurements of the YMO thin film were also performed. The bandgap energy of YMnO3 thin films was determined as 2.10 eV by UV-vis. The temperature-dependent reverse and forward bias I-V curves were evaluated in terms of thermionic emission (TE), Schottky emission, Fowler-Nordheim (F-N) tunneling and space charge-limited current (SCLC) current theories. Furthermore, it has been seen that the forward bias conduction in the junction at each temperature obeys F-N tunneling because of the linearity in the ln (I/V2) versus V-1 curves.
关键词： Polycrystalline,Heterojunction,Ferroelectric,Al/p-YMO/p-Si/Al,Schottky barrier,YMnO3,Temperature dependent current characteristics
更新于2025-09-23 15:23:52
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Minimal Timing Jitter in Superconducting Nanowire Single-Photon Petectors
摘要： Using a two-temperature model coupled with the modified time-dependent Ginzburg-Landau equation, we calculate the delay time τd in the appearance of a growing normal domain in the current-biased superconducting strip after absorption of the single photon. We demonstrate that τd depends on the place in the strip where the photon is absorbed and monotonically decreases with an increasing current. We argue that the variation of τd (timing jitter), connected either with position-dependent response or Fano fluctuations, could be as small as the lowest relaxation time of the superconducting order parameter, approximately ?/kBTc (Tc is the critical temperature of the superconductor), when the current approaches the depairing current.
关键词： position-dependent response,timing jitter,superconducting nanowire single-photon detectors,delay time,Fano fluctuations
更新于2025-09-23 15:23:52
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Influence of the position dependent effective mass on the nonlinear optical properties in semiparabolic and parabolic quantum well with applied magnetic field
摘要： In the current work, the nonlinear optical properties in GaAs/Ga1?xAlxAs semiparabolic and parabolic quantum well(QW) with constant effective mass(CEM) and position dependent effective mass(PDEM) are estimated for different applied magnetic field. In this regard, we have obtained the analytical expressions of the nonlinear rectification(OR), second harmonic generation(SHG), third harmonic generation(THG), optical absorption coefficients(OACs), and refractive index changes(RICs) by using the compact density matrix formalism. Simultaneously, we obtain the reliable energy eigenvalues and their corresponding eigenfunctions via the finite difference method. According to the obtained results, it is found that: (1)the correct inclusion of PDEM is the cause of a noticeable difference in nonlinear optical properties with respect to the use of CEM. (2)the applied magnetic field bear substantial technological importance in the process of nonlinear optical properties modulation.
关键词： Quantum well,Magnetic field,Position dependent effective mass,Optical properties
更新于2025-09-23 15:23:52
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Does the wavelength dependent photoisomerization process of the p?coumaric acid come out from the electronic state dependent pathways?
摘要： Similar to the anion photoactive yellow protein (PYP) chromophore, the neutral form of the PYP chromophore was also found to exhibit a the wavelength-dependent photoisomerization quantum yield. The isomerization quantum yield increases with the increasing excitation energy on the S1 state, while decreases when being excited to the S2 state. Does this wavelength dependent product yield come out from the specific reaction pathways of the S1 and S2 states? This would mean that, the relaxation pathway of the S2 state is distinct from that of the S1 state and does not involve twisting motion. Does it break Kasha's rule by exhibiting a direct transition from the S2 state to the ground state? The underlying mechanism needs further in. In this article, we employed the on-the-fly dynamics simulations and static electronic structure calculations to reveal the deactivation mechanism of the neutral form of the PYP chromophore. Our results indicated that the C_C twisting motion dominates the S1 state decay process. In contrast, for the decay process of the S2 state, an ultrafast transition from the S2 to the S1 state through a planar conical intersection is observed, and the excess energy activates a new reaction channel to the ground state characterized by a puckering distortion of the ring. This pathway competes with the photoisomerization channel. No direct transition from S2 to S0 is observed, hence Kasha's rule is valid for this process. Our calcualtions can provide a reasonable explanation of the wavelength-dependent isomerization quantum yield of neutral PYP chromophore, and we hope it can provide theoretical foundations for comparing the effect of protonation state on the dynamcal behaviors of PYP chromophore.
关键词： Wavelength dependent,Photoisomerization,Fluorescent protein,Nonadiabatic process
更新于2025-09-23 15:23:52
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Facet-Dependent Photocatalytic Behaviors of ZnS-Decorated Cu <sub/>2</sub> O Polyhedra Arising from Tunable Interfacial Band Alignment
摘要： ZnS particles were grown over Cu2O cubes, octahedra, and rhombic dodecahedra for examination of their facet-dependent photocatalytic behaviors. After ZnS growth, Cu2O cubes stay photocatalytically inactive. ZnS-decorated Cu2O octahedra show enhanced photocatalytic activity resulting from better charge carrier separation upon photoexcitation. Surprisingly, Cu2O rhombic dodecahedra give greatly suppressed photocatalytic activity after ZnS deposition. Electron paramagnetic resonance (EPR) spectra agree with these experimental observations. Time-resolved photoluminescence (TRPL) profiles provide charge transfer insights. The decrease in the photocatalytic activity is attributed to an unfavorable band alignment caused by significant band bending within the Cu2O (110)/ZnS (200) plane interface. A modified Cu2O–ZnS band diagram is presented. Density functional theory (DFT) calculations generating plane-specific band energy diagrams of Cu2O and ZnS match well with the experimental results, showing charge transfer across the Cu2O (110)/ZnS (200) plane interface would not happen. This example further illustrates that the actual photocatalysis outcome for semiconductor heterojunctions cannot be assumed because interfacial charge transfer is strongly facet-dependent.
关键词： interfacial charge transfer,zinc sulfide,cuprous oxide,facet-dependent properties,heterojunctions,band alignment
更新于2025-09-23 15:23:52
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Real-time estimation of time-dependent imposed heat flux in graded index media by KF-RLSE algorithm
摘要： Due to the large computational time caused by complex computational process of the existing inversion algorithm, real-time reconstruction of high-magnitude time-dependent heat flux in graded index media is quite challenging. In this study, based on hybrid technology of the Kalman filter and recursive least-square estimator (KF-RLSE), the real time reconstructed high-magnitude time-varying heat flux on graded index media surface, and the measurement information comes from the opposite side of the media. The ideal participating media, which is assumed to be isotropic scattering, constant thermophysical properties, and opaque and diffuse gray boundary, is employed to verify the reliability and validity of the proposed. All the reconstruction results show that the KF-RLSE algorithm can effectively reconstruct the boundary heat flux regardless of the positive or negative gradient of the refractive index. When the refractive index of each position increases or reduces, the transient heat flux on the surface can still be predicted effectively and acceptably. Furthermore, effects of different parameters on the accuracy and stability of the estimated results are also investigated. The reconstructed results show that the time-dependent heat flux can still be effectively reconstructed even when the measurement noise does not match its covariance. Meanwhile, the accuracy of the reconstruction results improves with the decrease of measurement noise covariance when the measurement noise distribution is fixed in a curtain range.
关键词： Recursive least squares estimator,Inverse radiation-conduction problem,Time-dependent heat flux,Graded index media,Kalman filter
更新于2025-09-23 15:23:52