- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Face and neck rejuvenation using an improved non-ablative fractional high power 1064-nm Q-switched Nd:YAG Laser: clinical results in 16 women
摘要： Objective: To evaluate the safety and efficacy of a specific treatment protocol using a new and improved non-ablative fractional high-power 1064-nm Q-switched Nd:YAG laser for face and neck rejuvenation. Methods: Sixteen women, aged 30 to 60 years old, were selected to undergo three consecutive treatment sessions with this new laser at maximum energy (2,400 mJ/pulse, Clear Lift laser?-Harmony XL-Pro, Alma Lasers Ltd.). Face and neck were treated in eight patients, respectively. Each treatment used the same protocol. The efficacy was evaluated by the therapist (TS), the patient (PS), and two separate independent experts who were blind to the study (E1 and E2). Results: According to E1 and E2, the mean reduction in signs of skin aging on a Global Esthetic Improvement Scale was 30-40%. Using a 0–10 points scale, TS and PS mean (range) satisfaction rates were 9.0 (8–10); 9.2 (6–10) for the face and 8.7 (8–10); 8.0 (3–10), for the neck, respectively. The procedure was practically painless, no significant adverse effects were observed, and the patients returned to their daily and work activities without downtime. Conclusion: This laser was safe and effective for face and neck minimally invasive rejuvenation, with excellent results using our usual routine use conditions.
关键词： fractionated laser,resurfacing,Q-Switched Nd:YAG laser,Skin rejuvenation,non-ablative laser
更新于2025-09-23 15:19:57
-
Fulla??face skin resurfacing using a combination of fractional and full spot ablative 2940??nm erbium laser
摘要： BACKGROUND: Full-field deep ablative laser resurfacing is a popular method for skin rejuvenation due to maximum improvement in a single treatment. However, it is associated with disadvantages such as pain, prolonged erythema, swelling, crusting, infections, pigmentary changes, and scarring. Patients are increasingly seeking less invasive options with comparable effect. AIMS: The aim of this retrospective study was to evaluate the safety and efficacy of full face resurfacing using a combination of full spot and fractional erbium (Er:YAG) laser resurfacing. PATIENTS/METHODS: 109 patients, mostly females over 50 years old, were treated with a two phase protocol: full spot ablation (5 J/cm2, three passes) and fractional ablation (132 J/cm2, 5% coverage, 3 passes). We recorded time to re-epithelization and duration of post-treatment erythema. Any side effects observed at follow-up or reported by the patient were recorded. Patient satisfaction questionnaire and blinded evaluation of pre and post treatment photographs were used to assess efficacy. RESULTS: A single session was performed in 96% of cases. Post-operative re-epithelization lasted on average 6.4±2.9 days. Post-treatment erythema lasted on average 13.8±15.2 days. One patient had hyperpigmentation, one infection, one hypo-pigmentation, and one ulcer. All side effects resolved without complications. According to the blinded assessment of photographs 78% of patients showed improvement. 97% of patients were satisfied with the results of the treatment. CONCLUSIONS: A combination of fractional and full spot ablative Er:YAG laser is a safe and effective option for full face resurfacing.
关键词： patient satisfaction,improvement,fractional,skin resurfacing,laser,erbium
更新于2025-09-23 15:19:57
-
Hybrid Fractional Ablative and Nonablative Laser Resurfacing of Actinic Keratoses
摘要： Field treatment of actinic keratoses (AKs) is a therapeutic challenge due to lack of patient tolerability and compliance with traditional treatments. Actinic keratoses are a known risk factor for development of squamous cell carcinoma. Actinic keratoses may be treated with cryosurgery, topical immunomodulators, topical chemotherapy, electrodessication and curettage, and photodynamic therapy. Both cryosurgery and curettage can leave unsightly scars or permanent dyspigmentation. Topical immunomodulators and topical chemotherapy require patient compliance. Photodynamic therapy can be painful and requires strict sunlight avoidance. Laser resurfacing is emerging as a promising therapeutic option for AKs with low recurrence rate after treatment.1–4 We present a single treatment with a hybrid 1,470-nm diode/2,940-nm Er:YAG fractional laser (Halo; Sciton, Palo Alto, CA) as a novel method to treat AKs off the face.
关键词： hybrid fractional laser,actinic keratoses,treatment,laser resurfacing
更新于2025-09-16 10:30:52
-
The Elite Facial Surgery Practice (Development and Management) || 24 Laser Surgery
摘要： All lasers are not the same. They are tools or instruments that come in a variety of different forms and are designed to perform different tasks. Some lasers vaporize the outer layers of sun-damaged or aging skin. Some can also pass through the outer layers of the skin and destroy deeper birthmarks (port-wine stains) or tiny blood vessels (spider veins.) As is the case with most technology, the use of lasers is an art form that improves with training and experience. Lasers, like any technology, must be used for the right reasons. The right reason is that, in the facial surgeon's opinion, it is superior to other forms of treatment, in terms of safety and outcomes. For some conditions, lasers exceed other forms of treatment. For others, I have found laser therapies to be inferior. So, if training in dermabrasion and chemical peeling was not offered during residency or fellowship, it is recommended that the surgeon arrange to spend enough time with a colleague who performs these procedures to feel comfortable offering and performing them.
关键词： Leg Veins,Rosacea,Laser Surgery,Pigmented Spots,Acne,Laser Hair Removal,Skin Resurfacing,Dilated Blood Vessels
更新于2025-09-16 10:30:52
-
Full-Field Erbium:YAG Laser Resurfacing: Complications and Suggested Safety Parameters
摘要： Background: Laser skin resurfacing with erbium-doped yttrium aluminum garnet (Er:YAG) lasers is a newer alternative to CO2 laser treatment, and was developed to reduce common complications. Although Er:YAG lasers have been available for years, safety parameters for efficacious resurfacing with these devices have not previously been available. Objectives: The aim of this study was to utilize one practice’s laser treatment settings and outcomes data to identify complication rates for various energies and areas of the face and to offer safe energy/depth parameters for treating each area. Methods: A retrospective chart review was performed for full-field confluent laser resurfacing patients treated with a Sciton Contour Tunable Resurfacing Er:YAG laser by the senior author. The data were retroactively analyzed with a time range of 8?years (January 2007-December 2015). Results: The overall complication rate for MicroLaserPeels (ablation of 50?μm or less) was 10.1% (20 of 198 treatments) and the rate for deep resurfacing treatments was 26.5% (71 of 268 cases). In MicroLaserPeel treatments the cheek area had the highest complication rate, followed by the forehead, nose, perioral, and eyelid areas, in that order (complication rate range, 0%-9.1%). In deep resurfacing treatments the perioral area had the highest complication rate, 38.6% of 145 cases. This was followed by the lids, cheek, nose, and forehead, in that order (complication rate range, 15.2%-20.9%). There is a correlation between increased depth of ablation and increased rate of complication. Conclusions: The study confirmed the efficacy of Er:YAG resurfacing and provides guidance for a safer approach to excellent outcomes.
关键词： complications,laser skin resurfacing,safety parameters,Er:YAG laser
更新于2025-09-16 10:30:52
-
Ablative fractional laser resurfacing for treatment of sclerosis and contractures in chronic graft-versus-host disease: A pilot study
摘要： To the Editor: Cutaneous sclerosis is a disabling complication of chronic graft-versus-host disease (cGVHD) that leads to joint contractures and reduced range of motion (ROM). Current therapies are limited by adverse effects and poor efficacy, and no systemic treatment successfully reverses cGVHD-induced sclerotic skin changes.1 There is an urgent need for therapies to address the debilitating effects of cutaneous sclerosis in cGVHD. The ablative fractional CO2 laser remodels collagen and reduces fibrosis. It has been used for treatment of scars and contractures secondary to linear morphea, burns, and traumatic injury, conditions resembling the sclerosis of cGVHD.2,3 We evaluated the safety, tolerability, and efficacy of the ablative fractional CO2 laser for cGVHD-related sclerosis and joint contractures. Six patients with cGVHD-related sclerosis were enrolled prospectively and completed the study. Eligible patients had clinically severe, refractory sclerosis from longstanding cGVHD, with demonstrable ROM limitation and contractures across a joint amenable to laser therapy. After administration of topical anesthesia, patients had 3 monthly treatments of an approximately 10 3 6-cm area of skin at the target joint using the 10 600-nm fractional Ultrapulse CO2 laser (Ultrapulse Encore; Lumenis, Inc, Santa Clara, CA) in Deep FX mode (energy settings, 20-25 mJ; density, 5%-15%). Photographs, ROM measurements, and high-resolution ultrasonography were recorded at baseline, 1 week after each laser session, and 3 months after the final session. Punch biopsy and patient and provider assessments, including validated health and disability questionnaires, were performed at baseline and 3 months after the final session. The study was approved by the University of Pennsylvania institutional review board, and all patients provided written informed consent. Before enrollment, patients had received a mean of 5.5 systemic therapies for cGVHD-related sclerosis. Laser treatments were well tolerated, without infectious or other serious complications. ROM measurements, particularly the twisting motions of supination and pronation, improved in all patients (Table I). Immunohistochemical analysis of skin biopsy specimens showed decreased thickened collagen bundles, decreased intensity of collagen staining, and greater abundance of type III collagen in treated areas (Fig 1).3 Dermal echogenicity measured via high-resolution ultrasonography increased after the laser treatment, suggestive of collagen remodeling. Less haphazard organization of collagen is postulated to produce increased echogenicity.4 Patient photographs and disability assessments similarly showed evidence of improvement. The results of this pilot study highlight the safety, tolerability, and potential efficacy of the fractional ablative CO2 laser for treatment of cGVHD-related sclerosis and joint contracture, resulting in small but measurable histologic, radiologic, and functional improvements. Small sample size, small treatment area, and imperfect objective response measures are limitations. Longer follow-up, larger treatment areas, use of other laser settings, and laser-assisted delivery of topical medications should be evaluated in future studies.5 In summary, the fractional ablative CO2 laser was safe and well tolerated in a small group of medically complex patients with treatment-refractory cGVHD. Treatment of a target area of sclerotic skin appeared to induce collagen remodeling, with resulting modest improvement in ROM and joint function. These findings suggest that the fractional ablative CO2 laser may be an effective novel therapy for disabling sclerotic joint contractures in some patients with cGVHD.
关键词： sclerosis,ablative fractional laser resurfacing,contractures,chronic graft-versus-host disease,collagen remodeling
更新于2025-09-16 10:30:52
-
Fractional Ablative Laser Therapy is an Effective Treatment for Hypertrophic Burn Scars
摘要： Objective: The aim of this study is to determine objective and subjective changes in mature hypertrophic burn scars treated with a fractional ablative carbon dioxide (CO2) laser. Background: Fractional CO2 laser treatment has been reported to improve burn scars, with increasing clinical use despite a paucity of controlled, prospective clinical studies using objective measures of improvement. Methods: A multicenter, site-controlled, prospective open-label study was conducted from 2013 to 2016. Objective and patient-reported outcome measures were documented at baseline, at each monthly laser treatment, and 6 months after treatment. Objective measurements employed were: mechanical skin torque to measure viscoelastic properties; ultrasonic imaging to measure scar thickness; and reflectometry to measure erythema and pigmentation. Subjective measures included health-related quality of life, patient and investigator scar assessment scales, and blinded scoring of before and after photographs. Subjects aged 11 years or older with hypertrophic burn scars were recruited. Each subject received 3 monthly treatment sessions with an ablative fractionated CO2 laser. Results: Twenty-nine subjects were enrolled, of whom 26 received at least 1 fractional CO2 laser treatment and 22 received 3 treatments. Mean age of those completing all 3 treatments was 28 years. Statistically significant objective improvements in elastic stretch (P < 0.01), elastic recovery (P < 0.01), extensibility (P < 0.01), and thickness (P < 0.01) were noted. Patient- and physician-reported scar appearance and pain/pruritus were significantly improved (P < 0.01). There was no regression of improvement for at least 6 months after treatment. Conclusions: Fractional ablative laser treatment provides significant, sustained improvement of elasticity, thickness, appearance, and symptoms of mature hypertrophic burn scars.
关键词： hypertrophic scar,burn,resurfacing,photothermolysis,skin elasticity,ablative,CO2 laser,laser,fractional
更新于2025-09-12 10:27:22
-
Treatment of Benign Adnexal Tumors in Birt–Hogg–Dubé Syndrome With Surgical Debulking in Combination With Fractional and Fully Ablative Carbon Dioxide Laser Resurfacing
摘要： Birt–Hogg–Dub′e syndrome (BHDS) is a rare autosomal dominant condition caused by germline mutations in the FLCN gene, which is associated with both cutaneous and extracutaneous manifestations. Cutaneous lesions include fibrofolliculomas and trichodiscomas, which are benign adnexal tumors presenting as smooth dome-shaped papules on the face, neck, and trunk. Extracutaneous manifestations include pulmonary cysts, spontaneous pneumothorax, and various renal tumors. Although benign, the cutaneous lesions may have profound psychological effects on patients given their propensity for the face. We present a case of a man with BHDS who was successfully treated with surgical debulking combined with fractional and fully ablative carbon dioxide (CO2) laser resurfacing.
关键词： fibrofolliculomas,CO2 laser resurfacing,surgical debulking,Birt–Hogg–Dub′e syndrome,BHDS,trichodiscomas
更新于2025-09-12 10:27:22
-
Ablative Fractional Laser Resurfacing
摘要： Normal wound healing is a well-orchestrated process that occurs in 3 characteristic overlapping phases after injury: in?ammation, proliferation, and remodeling/maturation. During the proliferation phase of healing, granulation tissue grows from the base of the wound, ?lling the volume de?cit of the wound, and facilitating epithelialization and wound closure. Aberrantly prolonged stimulation of ?broplasia and angiogenesis, believed to be caused by an imbalance of matrix metalloproteinases, results in hyper-granulation, or “proud ?esh.” Risk factors contributing to the development of hypergranulation include wounds that heal by secondary intention, a prolonged (>1 week) in?ammatory phase of healing, or exposure to excessive external friction or moisture. Hypergranulation is clinically identi?able as red, friable, exophytic tissue that spills over the edges of the wound. Its presence impedes normal wound healing, resulting in persistent wounds that diminish quality of life (pain, bleeding, or malodor), contributing to development of contractures in burn wounds and grafts, and increasing risk of subsequent infection. Treatment is often dif?cult, and multiple modalities have been reported in the literature with varying success including chemical cautery with silver nitrate or tricholoracetic acid, both intralesional or topical corticosteroids, hydrocolloid dressings, surgical excision, pulsed dye laser (PDL), and potassium titanyl phosphate (KTP) laser.1,2 Treatment of surgical, traumatic, and burn scars with the ablative fractional CO2 laser is a recent, highly successful development.3 This infrared laser targets water and vaporizes vertical microcolumns of tissue, creating a zone of coagulation surrounding the ablated microcolumns. After this controlled microscopic injury, a sequential and predictable induction of growth factors and cytokines occurs, leading to a coordinated expression of matrix metalloproteinases, growth factors, and heat-shock proteins.4 Three recently reported case series detail the successful treatment of 10 patients with chronic ulcers with ablative fractional laser resurfacing.3–5 In this report, we describe the successful treatment of 2 patients with hypergranulation tissue using ablative fractional laser resurfacing. To the best of our knowledge, this has not previously been described in the literature.
关键词： Ablative Fractional Laser Resurfacing,Pulsed Dye Laser,CO2 Laser,Hypergranulation Tissue,Wound Healing
更新于2025-09-12 10:27:22