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- 摘要
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- 实验方案
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Multifunctional Nanotheranostic Gold Nanocages for Photoacoustic Imaging Guided Radio/Photodynamic/Photothermal Synergistic Therapy
摘要： In this work, we developed a novel multifunctional nanoplatform based on hyaluronic acid modified Au nanocages (AuNCs-HA). The rational design of AuNCs-HA renders the nanoplatform three functionalities: (1) AuNCs-HA with excellent LSPR peak in the NIR region act as contrast agent for enhanced photoacoustic (PA) imaging and photothermal therapy (PTT); (2) the nanoplatform with high-energy rays (X-ray) absorption and auger electrons generation acts as a radiosensitizer for radiotherapy; (3) good photocatalytic property and large surface area make AuNCs-HA a photosensitive agent for photodynamic therapy (PDT). In vivo results demonstrated that AuNCs-HA presented excellent PA imaging performance after intravenous injection, which provided contour, size, and location information of the tumor. Moreover, because AuNCs-HA could combine radiotherapy and phototherapy together, the tumors treated with AuNCs-HA showed complete growth inhibition, comparing to that with each therapy alone. Taken together, our present study demonstrates that AuNCs-HA is of great potential as a multifunctional nanoplatform for PA imaging-guided radio- and photo-therapy of tumor.
关键词： PTT,Au nanocages,radiotherapy,PDT,theranostic nanoplatform,PA imaging
更新于2025-09-23 15:21:21
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Supramolecular Valves Functionalized Rattle-Structured UCNPs@hm-SiO2 Nanoparticles with Controlled Drug Release Triggered by Quintuple Stimuli and Dual-modality Imaging Functions: A Potential Theranostic Nanomedicine
摘要： Integrating multimodality bioimaging and multiple stimuli-responsive controlled drug release properties into one single nanosystem for therapeutic application is highly desirable, but still remains a challenge. Herein, we coated a hollow mesoporous silica shell onto upconversion nanoparticles (UCNPs), conjugated pillarene-based supramolecular valves onto surface of UCNPs@hm-SiO2 using amine-coumarin phototriggers to obtain the multifunctional nanoparticles, UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5]. Benefiting from the core-shell structured UCNPs, the UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5] can serve as the efficient contrast agents for upconversion luminescence and T1-weighted magnetic resonance imaging in vitro/in vivo. More importantly, depending on exquisitely designed supramolecular valves, UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5] can realize zero-premature release under normal physiological conditions (pH 7.4), which produces the minimal damage to normal tissue, whereas this nanosystem can respond to several disease-related signals including acid (most cancers), alkali (metabolic alkalosis), and Zn2+ (Alzheimer’s disease) along with two external stimuli including near infrared (NIR) light and reductive electrical potential via altering spatial structure of pseudorotaxanes, disassembling the molecular stalks, or undergoing photochemical reactions, ultimately resulting in opening of the gatekeepers and release of encapsulated drugs. The multifunctional UCNP-based nanoparticles were endowed with such quintuple stimuli-responsive controlled release characteristics. Specifically, in anticancer application, the rational utilization of the two of them, acid and NIR light, could regulate the release amount and rate of DOX from UCNPs@hm-SiO2-Cou-Cys-DOX/WP[5], accelerate the accumulation of DOX in cell nuclei and thereby promote the cancer cell apoptosis, indicating that the nanomaterials have promising application in cancer treatment. This study provides a novel design strategy for constructing multifunctional UCNP-based nanoparticles with multiple stimuli-responsive drug release features, which have great potential in diagnosis and therapy of relevant diseases as theranostic nanomedicines.
关键词： upconversion nanoparticles,Supramolecular nanovalve,theranostic nanoplatform,quintuple stimuli-responsiveness
更新于2025-09-19 17:13:59
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Designing of UCNPs@Bi@SiO2 Hybrid Theranostic Nanoplatforms for Simultaneous Multimodal Imaging and Photothermal Therapy
摘要： Herein, a novel multifunctional nanoplatform was designed towards multimodality imaging and photothermal therapy (PTT). It was found that Bi nanoparticles could grow in situ on the surface of NaYF4:20%Yb,2%Er@NaYF4:40%Yb@NaGdF4 core-shell nanoparticles (labeled as UCNPs). In this structure, UCNPs were mainly employed as upconversion luminescence (UCL) imaging agent, while the Bi nanoparticles worked as effective CT imaging and photothermal agent. Importantly, a dense SiO2 shell was employed to protect the Bi nanoparticles from oxidation, and it also endowed the nanoplatform with excellent hydrophilic ability. The effective UCL/CT imaging and PTT performances were emphasized by a series of in vivo experiments, which suggest that the integrated nanoplatform with imaging and therapy functions show great promise in the biomedical field.
关键词： Theranostic Nanoplatform,UCL imaging,CT imaging,Photothermal Therapy,UCNPs
更新于2025-09-04 15:30:14