Unsaturation‐dependent Nanostructures Self‐assembled from Oligopeptide Amphiphile Capable of Generating Singlet Oxygen

摘要： We report here on three oligopeptide amphiphiles (OPA1-3) with different unsaturated double bonds, which self-assemble into shape-specific nanostructures. It was found that OPA1 with saturated hydrophobic tail self-assembled into conventional cylindrical nanofibers, while the unsaturated OPA2-3 molecules self-organized into helical nanoarchitectures. Due to the different double bond numbers in hydrophobic tails of OPA2-3, the helical pitch and width of their self-assemblies varied. Specially, linoleic acid-bearing OPA3 could be oxidized by lipoxidase to create hydroperoxide-containing OPA4, which further generated singlet oxygen (1O2) in the presence of catalytic iron (II) ion. The established system may provide a self-deliverable nanoplatform for 1O2-mediated cancer treatment.