1：Experimental Design and Method Selection:

The study involved the synthesis of graphene on Cu foil using LPCVD, followed by a fast cooling process to induce wrinkles. Hydrogen etching experiments were then conducted to study the etching behavior of wrinkled graphene domains.

2：Sample Selection and Data Sources:

Graphene samples were grown on electrochemically polished Cu foil. The samples were characterized using optical microscopy, Raman spectroscopy, AFM, and SEM.

3：List of Experimental Equipment and Materials:

A 25 μm thick Cu sheet was used for graphene synthesis. The LPCVD system (Xiamen G-CVD) was employed for graphene growth. Characterization was performed using a digital optical microscope (MV5000), SEM (Sigma, Zeiss Inc.), Raman spectrometer (Alpha-300, WITec), and AFM (Dimension Icon, Bruker).

4：Experimental Procedures and Operational Workflow:

The Cu foil was folded into a pocket-like structure, loaded into the LPCVD system, and heated under specific gas flows for graphene growth. After growth, the system was cooled down at different rates. The samples were then annealed in Ar/H2 gas mixture for etching studies.

5：Data Analysis Methods:

The morphology and structure of the graphene samples were analyzed using optical microscopy, SEM, AFM, and Raman spectroscopy. Statistical analysis was performed to quantify etching preferences on wrinkled sites.