研究目的
To compare the visual and refractive outcomes after myopic LASEK using three different excimer lasers and standardized surgical and mitomycin C (MMC) application protocols.
研究成果
In conclusion, we found subtle postoperative differences favouring the Allegretto excimer laser after myopic LASEK surgery with a standardized surgical and MMC protocol when studying matched populations. However, it should be noted that these differences are so small that they have no clinical impact.
研究不足
The study is limited by its retrospective design and the potential biases inherent in such studies, including selection bias and information bias. Additionally, the study only included patients younger than 40 years, which may limit the generalizability of the findings to older populations.
1：Experimental Design and Method Selection:
A retrospective, observational cohort study design was used to compare the outcomes of myopic LASEK using three different excimer lasers.
2：Sample Selection and Data Sources:
394 eyes from consecutive patients younger than 40 years who underwent LASEK for the correction of myopia with or without astigmatism between 2005 and
3：List of Experimental Equipment and Materials:
20 Allegretto, Esiris, and Technolas excimer lasers; mitomycin C (MMC); balanced salt solution (BSS); povidone-iodine solution 5%; lidocaine 2%; ethanol solution 20%; cellulose sponge; crescent blade; therapeutic soft contact lens; antibiotic drops; nonsteroidal anti-inflammatory drops; steroid drops; preservative-free artificial tears.
4：Experimental Procedures and Operational Workflow:
All surgeries were performed under topical anesthesia. A standardized surgical protocol was followed, including the application of MMC and the use of a therapeutic soft contact lens postoperatively.
5：Data Analysis Methods:
Statistical analysis was performed with the 'Statview SE + Graphics' program. A decimal scale was used for visual acuity measurements and converted to LogMAR for statistical analysis. The Kolmogorov-Smirnov test was used to check normality of the distribution, and a factorial ANOVA test was used for analysis.
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Allegretto
400 Hz
WaveLight Laser Technologie AG
Excimer laser for corneal ablation in refractive surgery
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Esiris
Schwind eye-tech-solutions Gmbh & Co
Excimer laser for corneal ablation in refractive surgery
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Technolas
517c
Bausch & Lomb Surgical
Excimer laser for corneal ablation in refractive surgery
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Nidek autochart projector
CP 670
Nidek
Measurement of corrected distance visual acuity (CDVA)
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DGH 5100 contact pachymeter
DHG Technology Inc.
Ultrasound corneal pachymetry
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OcuScan RXP
Alcon Laboratories, Inc.
Ultrasound corneal pachymetry
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Dicon CT200
Vismed Inc.
Topography/tomography and keratometry
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CSO Costruzione Strumenti Oftalmici
Topography/tomography and keratometry
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Colvard Pupillometer
Oasis 78 Medical Inc.
Mesopic infrared pupillometry
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