研究目的
Investigating the use of optical fiber sensors for monitoring key physiological and pharmacological parameters in critical care, specifically for respiration monitoring and drug level monitoring.
研究成果
Optical fiber sensors offer a flexible platform technology for monitoring in critical care, with demonstrated applications in respiration rate monitoring and potential for drug level monitoring. Further research is needed to optimize functional coatings for lower detection limits and to expand the range of monitored parameters.
研究不足
The detection limit for fentanyl (50ng/ml) is higher than the concentrations required in critical care (26ng/ml), indicating a need for further optimization of the coating. The study also mentions future work to adapt the approach for monitoring other breath properties.
1：Experimental Design and Method Selection:
The study utilizes optical fiber sensors (OFS) configured for monitoring temperature, humidity, and drug concentrations. Two main configurations are demonstrated: a fiber Bragg grating (FBG) for temperature and humidity monitoring, and a long period grating (LPG) coated with molecularly imprinted polymer nanoparticles for fentanyl detection.
2：Sample Selection and Data Sources:
For respiration monitoring, a sample of 20 volunteers was used with ethics approval. For fentanyl detection, in vitro tests were conducted with various concentrations of fentanyl/water solutions.
3：List of Experimental Equipment and Materials:
Includes boron doped photosensitive fiber, UV laser inscription system, SLD light source, spectrometer, medical hypodermic needle, and various chemical reagents for coating processes.
4：Experimental Procedures and Operational Workflow:
Detailed steps for coating the optical fibers, setting up the OFS in masks or nasal cannulas, and conducting measurements with volunteers and in vitro tests.
5：Data Analysis Methods:
Analysis of wavelength shifts and intensity changes in the reflected or transmitted spectra to determine temperature, humidity, and fentanyl concentration.
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spectrometer
I-MON512
Ibsen Photonics A/S
Records the reflected spectrum from the OFS.
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halogen light source
HL-2000
Ocean Optics
Launches light through the LPG for fentanyl detection.
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CCD spectrometer
USB2000
Ocean Optics
Records the transmission spectrum for fentanyl detection.
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boron doped photosensitive fiber
PS1250
Fibercore
Used for writing FBGs for temperature and humidity monitoring.
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UV laser inscription system
Frequency-quadrupled Nd:YAG, 266 nm
Continuum Minilite I
Used for inscribing FBGs into the optical fiber.
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SLD light source
SUPERLUM
Emits a spectrum centered at 1550 nm for interrogating the OFS.
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medical hypodermic needle
23-gauge
Protects the humidity sensing film and the sensing FBG.
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