研究目的
To evaluate the ablation capacity using two Thulium fiber lasers (TFL) in a porcine kidney model.
研究成果
This ex vivo study shows that variation in the laser fiber diameter has none-to-minimal impact on such parameters of the laser-induced wound as VV, AD, TMD, and CZ in a porcine kidney model, for both cw and SP TFL. However, the cw TFL produces a significantly larger CZ and results in a more pronounced carbonization than the SP TFL. These findings suggest that the SP TFL is a promising alternative to already established lasers for cutting soft tissue, with an even better safety profile and less collateral damage.
研究不足
The study used an isolated non-perfused porcine kidney model, which cannot be directly applied to a human prostate. The small sample size may have affected the significance of the results. Environmental differences and personal bias of the investigators could also influence the histological findings.
1：Experimental Design and Method Selection:
The study used a continuous wave (cw) TFL and a super pulsed (SP) TFL at power settings of 60 and 120 W with 200 and 600 μm laser fibers.
2：Sample Selection and Data Sources:
Fresh non-frozen porcine kidney was cut into 8 × 4 cm pieces and fixed on a motorized translation XY stage.
3：List of Experimental Equipment and Materials:
cw TFL (120 W peak power, NTO IRE-Polus, Fryazino, Russia) and SP TFL (1000 W peak power, NTO IRE-Polus, Fryazino, Russia).
4：Experimental Procedures and Operational Workflow:
The handpiece of the laser fiber was mounted at the XY stage allowing a constant working distance of the fiber to the soft tissues surface (
5：5 mm) with a continuous speed of cutting of 2 mm/s. Data Analysis Methods:
Histological evaluation was performed to measure the vaporization volume (VV), ablation depth (AD), thermo-mechanical damage zones (TMZ), coagulation zones (CZ) and the carbonization grade (CG).
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