研究目的
To explore the potential of Bi2O2Se quantum dots (QDs) as a photothermal therapy (PTT) agent and photoacoustic (PA) imaging agent for cancer treatment.
研究成果
Bi2O2Se QDs are prepared from bulk crystals by a facile solution-based method and the effectiveness as PA imaging and PTT agents is assessed. The Bi2O2Se QDs with a size of 3.8 nm and thickness of 1.9 nm deliver excellent NIR photothermal performance such as a large photothermal conversion coefficient of 35.7% and good photothermal stability. The Bi2O2Se QDs are highly efficient PA imaging and PTT agents in vitro and in vivo. After systemic administration, the Bi2O2Se QDs accumulate passively in tumors enabling efficient PA imaging of the entire tumors to facilitate photothermal cancer therapy. Furthermore, the Bi2O2Se QDs are degradable, nontoxic, and can be efficiently cleared from the body harmlessly after therapy. The results reveal the strong potential of Bi2O2Se QDs in imaging-guided PTT for precision cancer treatment.
研究不足
The study focuses on the synthesis and initial in vitro and in vivo assessments of Bi2O2Se QDs. Long-term toxicity and the mechanism of degradation in vivo require further investigation.
1：Experimental Design and Method Selection:
A solution-based method to synthesize Bi2O2Se QDs from bulk Bi2O2Se crystals was described for the first time and implemented as a theranostic platform for PTT.
2：Sample Selection and Data Sources:
The Bi2O2Se QDs were characterized by TEM, HR-TEM, AFM, and Raman scattering spectroscopy.
3：List of Experimental Equipment and Materials:
Materials included stoichiometric high-purity Bi2O3 powder, Se powder, Bi powder, and NMP. Equipment included SEM (HITACHI SU8010), TEM (JEOL JEM-2010), XPS (Axis Ultra spectrometer), XRD (SmartLab with Cu Kα radiation), AFM (MFP-3D-S AFM), and ICP-AES (IRIS Intrepid II XSP).
4：Experimental Procedures and Operational Workflow:
The Bi2O2Se QDs were prepared by a modified liquid exfoliation technique. The dispersion was sonicated for 20 h in an ice bath at 300 W and again with a sonic tip for another 20 h.
5：Data Analysis Methods:
The photothermal conversion efficiency was determined based on the previously reported method.
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SEM
SU8010
HITACHI
Characterization of bulk Bi2O2Se crystals
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TEM
JEM-2010
JEOL
Characterization of Bi2O2Se QDs
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XRD
SmartLab
Bruker D8 Advance
Characterization of bulk Bi2O2Se crystals
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ICP-AES
IRIS Intrepid II XSP
Thermo Electron Corporation
Determination of Bi2O2Se concentration
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Infrared thermal imaging camera
Ti27
Fluke
Monitoring temperature changes
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Bi2O3 powder
99.999%
Aladdin Reagents
Raw material for synthesis of Bi2O2Se crystals
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Se powder
99.999%
Aladdin Reagents
Raw material for synthesis of Bi2O2Se crystals
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Bi powder
99.999%
Aladdin Reagents
Raw material for synthesis of Bi2O2Se crystals
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NMP
Aladdin Reagents
Solvent for synthesis of Bi2O2Se QDs
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XPS
Axis Ultra spectrometer
PHI VersaProbe II
Characterization of bulk Bi2O2Se crystals
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AFM
MFP-3D-S
Asylum Research
Characterization of Bi2O2Se QDs
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UV–vis–NIR spectrophotometer
TU-1810
Purkinje General Instrument Co., Ltd.
Absorption spectra collection
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NIR laser
KS-810F-8000
Kai Site Electronic Technology Co., Ltd.
Photothermal heating
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PA imaging system
Vevo 2100 LAZR
Visual Sonics Inc.
In vitro and in vivo PA imaging
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